ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Adrenocorticotropic hormone enhances the masculinity of an electric communication signal by modulating the waveform and timing of action potentials within individual cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Derived loss of signal complexity and plasticity in a genus of weakly electric fish.The Journal of experimental biology · 2021Article
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Ionic mechanisms of microsecond-scale spike timing in single cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Behavioral ecology, endocrinology and signal reliability of electric communication.The Journal of experimental biology · 2013Review
- Social regulation of electric signal plasticity in male Brachyhypopomus gauderio.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.Journal of neurophysiology · 2013Article
- Signal modulation as a mechanism for handicap disposal.Animal behaviour · 2012Article
- Testosterone and 11-ketotestosterone have different regulatory effects on electric communication signals of male Brachyhypopomus gauderio.Hormones and behavior · 2011Article
- Energetic cost of communication.The Journal of experimental biology · 2011Article
- Social competition affects electric signal plasticity and steroid levels in the gymnotiform fish Brachyhypopomus gauderio.Hormones and behavior · 2009Article
- From molecules to behavior: organismal-level regulation of ion channel trafficking.PLoS biology · 2009Article
- Circadian and social cues regulate ion channel trafficking.PLoS biology · 2009Article
- Androgens enhance plasticity of an electric communication signal in female knifefish, Brachyhypopomus pinnicaudatus.Hormones and behavior · 2009Article
- Melanocortins regulate the electric waveforms of gymnotiform electric fish.Hormones and behavior · 2009Article
- Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus.Hormones and behavior · 2008Article
- Circadian rhythms in electric waveform structure and rate in the electric fish Brachyhypopomus pinnicaudatus.Physiology & behavior · 2007Article
- Regulation and modulation of electric waveforms in gymnotiform electric fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Review
- Signal Cloaking by Electric Fish.BioscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We report here that melanocortin peptides appear to serve as the mechanism by which weakly electric fish couple socially regulated and stress-regulated brain pathways to unique changes in the intrinsic excitability and action potential waveform of excitable membranes in peripheral cells involved in communication. Gymnotiform electric fish modulate their electric organ discharges (EODs) by reshaping the electric discharges of excitable cells in the periphery. These fish show circadian enhancement of the EOD waveform. They also enhance their EOD waveforms within minutes in response to stressors and changes in the social environment, thus altering the communication value of the signal. Changes in the EOD waveform that occur within minutes result from changes in the discharges of individual electrocytes (microEODs) mediated by the cAMP/protein kinase A (PKA) pathway acting on ion channel kinetics. What activates the cAMP/PKA pathway in electrocytes has not been identified. In vivo injections of the melanocortin peptide adrenocorticotropic hormone (ACTH) increase the amplitude and duration of the electric signal waveform of the gymnotiform Brachyhypopomus pinnicaudatus over the course of 1 h. Applied to single electrocytes in vitro, ACTH increases microEOD amplitude and duration within minutes by differentially modulating the action potentials of the two excitable membranes of the electrocyte and changing the timing of these two spikes. Serotonin modulates the EOD in vivo but has no effect on the microEOD in vitro. The cAMP analog 8-bromo-cAMP mimicked the effects of ACTH, whereas inhibition of PKA by protein kinase A inhibitor 14-22 amide blocked the modulatory effects of ACTH, confirming the role of the cAMP/PKA pathway in microEOD modulation by ACTH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.