ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Downregulation of platelet-derived growth factor-alpha receptor-mediated tyrosine kinase activity as a cellular mechanism for K+-channel regulation during oligodendrocyte development in situ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Oligodendrocyte precursor cell maturation: role of adenosine receptors.Neural regeneration research · 2021Review
- AFrontiers in neuroscience · 2021Review
- Activity-dependent central nervous system myelination throughout life.Journal of neurochemistry · 2019Review
- Role of adenosine in oligodendrocyte precursor maturation.Frontiers in cellular neuroscience · 2015Review
- NG2 cells in white matter but not gray matter proliferate in response to PDGF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neuron-NG2 cell synapses: novel functions for regulating NG2 cell proliferation and differentiation.BioMed research international · 2013Review
- Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.Nature neuroscience · 2010Article
- Crucial role of the local micro-environment in fate decision of neonatal rat NG2 progenitors.Cell proliferation · 2009Article
- Article
- Synapses on NG2-expressing progenitors in the brain: multiple functions?The Journal of physiology · 2008Review
- Satellite NG2 progenitor cells share common glutamatergic inputs with associated interneurons in the mouse dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter.Nature neuroscience · 2008Article
- Differential synaptic integration of interneurons in the outer and inner molecular layers of the developing dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Neurotransmitter receptors in the life and death of oligodendrocytes.Neuroscience · 2007Review
- Identification of Sox17 as a transcription factor that regulates oligodendrocyte development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oligodendrocyte maturation has been defined based on expression of developmentally regulated antigens. However, transitions at early stages of the lineage have not been functionally characterized fully in situ. Combining 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP)-promoter driven enhanced green fluorescent protein expression and whole-cell capacitance measurements permitted a reliable distinction between subcortical white matter NG2+ oligodendrocyte progenitors (OPs) and O4+ preoligodendrocytes (pre-OLs) in situ. We focused on K+ channels because their expression has been associated previously with the proliferation and differentiation potential of OPs. Using whole-cell patch clamp, we observed a downregulation of the delayed outward-rectifying current (IKDR) between the NG2+ and O4+ stages but no significant changes in transient K+-channel current (IKA) amplitude. Tyrosine kinase inhibition in NG2+ cells reduced IKDR amplitude with no effect on IKA, which mimicked the endogenous changes observed between OPs and pre-OLs. Tyrosine kinase inhibition also reduced the proliferative capacity of NG2+ OPs in slice cultures. Conversely, acute platelet-derived growth factor receptor-alpha (PDGFR-alpha) activation caused an increase of IKDR in NG2+ but not in O4+ cells. Consistent with this finding, PDGFR-alpha immunoreactivity was confined to NG2+ cells with undetectable levels in O4+ cells, suggesting that PDGFR-alpha signaling is absent in pre-OLs in situ. Importantly, the PDGF-induced increase of IKDR in NG2+ cells was prevented by tyrosine kinase inhibition. Together, these data indicate that PDGFR-alpha and tyrosine kinase activity act via a common pathway that influences functional expression of K+ channels and proliferative capacity of OPs in situ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.