ArticleAnnals of the rheumatic diseases2006
Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Fc receptor-like 3 -169 C/T polymorphism and RA susceptibility: a meta-analysis.Rheumatology international · 2010Pooled it
- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.Arthritis research & therapy · 2009Pooled it
- Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.Journal of human genetics · 2008Pooled it
- Impacts of rs7528684 (-169T/C) onFrontiers in genetics · 2025Article
- Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis.Gastroenterology research and practice · 2017Review
- Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.Rheumatology international · 2016Article
- Four FCRL3 Gene Polymorphisms (FCRL3_3, _5, _6, _8) Confer Susceptibility to Multiple Sclerosis: Results from a Case-Control Study.Molecular neurobiology · 2016Article
- MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients.Rheumatology international · 2016Article
- Article
- Genetic associations of FCRL3 polymorphisms with the susceptibility of Graves ophthalmopathy in a Chinese population.International journal of clinical and experimental medicine · 2015Article
- Genetic studies of rheumatoid arthritis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2015Review
- Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies.Journal of clinical immunology · 2012Article
- Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population.Clinical rheumatology · 2012Article
- Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis.Nature reviews. Rheumatology · 2010Review
- Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.Molecular vision · 2009Article
- A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.PLoS genetics · 2008Article
- Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis.Journal of gastroenterology · 2008Review
- Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.Arthritis research & therapy · 2008Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between susceptibility to rheumatoid arthritis and the Fc receptor-like 3 gene (FCRL3) has been reported in a Japanese population. A case-control study showed that the strongest evidence of the association was derived from a polymorphism in the promoter region of FCRL3, which has a regulatory effect on the expression of the gene.
objectiveTo validate the findings of this previous report by examining the -169C-->T single nucleotide polymorphism (SNP) in a large cohort.
methods752 unrelated cases and 940 controls were genotyped. All the samples were from the same ethnic background as the original study. Genotyping was done using 5' allelic discrimination assays. Association between susceptibility to rheumatoid arthritis and -169C-->T SNP was examined by chi(2) testing.
resultsAs in the previous study, the SNP showed significant differences between cases and controls (p = 0.022, odds ratio = 1.18, 95% confidence interval 1.02 to 1.35).
conclusionsThis result supports a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis.
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