Evidence map›Paper›PMID 16176721›Full record

ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2005

Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later.

Terry Reed, Brenda L Plassman, Caroline M Tanner, Danielle M Dick, Shannon A Rinehart, William C Nichols

Open access · greenAbstract readTwin Study
In one paragraph

Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 68 citations in OpenAlex.

  1. Trial
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  7. The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  8. Heritability of Craniofacial Characteristics in Twins - Cephalometric Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019
    Article
  9. Article
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  11. Article
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  14. Coping Styles in Twins Discordant for Schizophrenia, Bipolar Disorder, and Depression.Clinical psychological science : a journal of the Association for Psychological Science · 2016
    Article
  15. Article
  16. Article
  17. Does caregiving cause psychological distress? The case for familial and genetic vulnerabilities in female twins.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014
    Article
  18. Salivary cortisol and cold pain sensitivity in female twins.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014
    Article
  19. Article
  20. Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Terry ReedDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. treed@iupui.edu
Brenda L Plassman
Caroline M Tanner
Danielle M Dick
Shannon A Rinehart
William C Nichols
Indiana University – Purdue University Indianapolis · USCincinnati Children's Hospital Medical Center · USDuke University Hospital · USParkinson's Institute and Clinical Center · US

Funding

GENETIC EPIDEMIOLOGY OF ALZHEIMER'S DISEASE IN TWINSR01AG008549 · NIA · DUKE UNIVERSITY · PI PLASSMAN, BRENDA L · 1989 to 2003
$4.2M
TWINS AND RISK OF PD: A CLINICAL AND IMAGING STUDYR01NS040467 · NINDS · PARKINSON'S INSTITUTE · PI TANNER, CAROLINE M. · 2000 to 2004
$3.4M
GENETIC STUDIES OF GOOD HEALTH IN AN AGING TWIN COHORTR01AG018736 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI REED, TERRY EUGENE · 2000 to 2002
$1.1M
TWIN STUDIES IN PARKINSONS DISEASEU10NS031321 · NINDS · PARKINSON'S INSTITUTE · PI TANNER, CAROLINE M. · 1992 to 1999
–
NIA NIH HHS AG08549NIA NIH HHS AG18736NIA NIH HHS R01 AG008549NIA NIH HHS R01 AG018736NINDS NIH HHS NS31321NINDS NIH HHS NS40467NINDS NIH HHS R01 NS040467
6 · The paper itself

Abstract

The National Academy of Sciences -- National Research Council (NAS-NRC) twin panel, created nearly 50 years ago, had twin zygosity determined primarily via a similarity questionnaire that has been estimated to correctly classify at least 95% of twins. In the course of a study on the genetics of healthy ageing in the NAS-NRC twins, DNA was collected for genome-wide scanning and zygosity confirmation was examined in 343 participating pairs. The sample was supplemented from two other studies using NAS-NRC twins where one or both co-twins were suspected to have Alzheimer disease or another dementia, or Parkinson's disease. Overall 578 twin pairs with DNA were analyzed. Zygosity assignment for 96.8% (519/536) was confirmed via questionnaire. Among 42 pairs whose questionnaire responses were inconclusive for assigning zygosity, 50% were found to be monozygous (MZ) and 50% were dizygous (DZ). There was some evidence for greater misclassification of presumed DZ pairs in the healthy ageing study where participation favored pairs who were similar in having a favorable health history and willingness to volunteer without any element of perceived risk for a specific disease influencing participation.

Indexed as

AdultAgedDNAGenotypeHumansSurveys and QuestionnairesTwins, DizygoticTwins, MonozygoticDNA

Identifiers

PMID16176721
PMCPMC1262657
OpenAlexW2008440492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.