ArticleNeurochemical research2005
Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid.
Article in Neurochemical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- A ROCK Inhibitor Promotes Graft Survival during Transplantation of iPS-Cell-Derived Retinal Cells.International journal of molecular sciences · 2021Article
- ROCK Inhibitor Y-27632 Promotes Human Retinal Pigment Epithelium Survival by Altering Cellular Biomechanical Properties.Current molecular medicine · 2017Article
- Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways.Molecular therapy. Methods & clinical development · 2015Article
- N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells.PloS one · 2015Article
- Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Small GTPases · 2014Review
- Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.The Journal of experimental medicine · 2012Article
- The bradykinin B(2) receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines.Cancer management and research · 2012Article
- Article
- Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling.PloS one · 2010Article
- Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions.European archives of psychiatry and clinical neuroscience · 2010Article
- Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.BMC neuroscience · 2008Article
- Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells.Molecular and cellular biochemistry · 2008Article
- Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage.Molecular and cellular biochemistry · 2008Article
- Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.The Journal of biological chemistry · 2007Article
- Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression.Journal of molecular signaling · 2007Article
- The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.Molecular and cellular biology · 2006Article
- The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death.Pflugers Archiv : European journal of physiology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied pathways involved in the proliferation of rat C6 glioma cells induced by lysophosphatidic acid (LPA), a phospholipid with diverse biological functions. LPA induced a dose-responsive proliferation of C6 cells after 48 h. Proliferation was blocked by inhibitors of the sodium/proton exchanger type 1 (NHE1), Rho-associated kinase, the phosphatidylinositol 3-kinase/Akt pathway (PI3K/Akt), protein kinase C (PKC) and extracellular signal regulated kinase kinase (MEK). Phospho-specific antibodies were used to investigate the pathways involved. LPA induced transient (10 min) phosphorylations of ERK 1/2, Akt and the transcription factor CREB. The LPA-induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K, PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor. Inhibition of Rho kinase or NHE1 did not reduce the LPA-induced phosphorylation of ERK, Akt or CREB. The results were compared with the effects of LPA on transduction pathways in other cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.