ArticleAmerican journal of human genetics2005
The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Investigation of RFLP Haplotypes β-Globin Gene Cluster in Beta-Thalassemia Patients in Central Iran.International journal of hematology-oncology and stem cell research · 2019Article
- Complex signatures of natural selection at GYPA.Human genetics · 2018Article
- ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in β-thalassaemia.Molecular genetics and genomics : MGG · 2018Article
- Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Review
- Computer simulation of human leukocyte antigen genes supports two main routes of colonization by human populations in East Asia.BMC evolutionary biology · 2015Article
- Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.PLoS genetics · 2014Article
- Inferring selection intensity and allele age from multilocus haplotype structure.G3 (Bethesda, Md.) · 2013Article
- Resistance to malaria in humans: the impact of strong, recent selection.Malaria journal · 2012Review
- Genome-wide detection of natural selection in African Americans pre- and post-admixture.Genome research · 2012Article
- Article
- Population genetics of malaria resistance in humans.Heredity · 2011Review
- Evidence for epistasis between hemoglobin C and immune genes in human P. falciparum malaria: a family study in Burkina Faso.Genes and immunity · 2011Article
- Article
- Human genetic differentiation across the Strait of Gibraltar.BMC evolutionary biology · 2010Article
- β-globin haplotypes in normal and hemoglobinopathic individuals from Reconcavo Baiano, State of Bahia, Brazil.Genetics and molecular biology · 2010Article
- Evidence of gene conversion in the evolutionary process of the codon 41/42 (-CTTT) mutation causing beta-thalassemia in southern China.Journal of molecular evolution · 2008Article
- Evolutionary analysis of genes of two pathways involved in placental malaria infection.Human genetics · 2008Article
- African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.Annual review of genomics and human genetics · 2008Review
- Detecting the Genetic Signature of Natural Selection in Human Populations: Models, Methods, and Data.Annual review of anthropology · 2008Article
- Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations.BMC genetics · 2007Article
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5 authors.
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Abstract
Recombination is expected to reduce the effect of selection on the extent of linkage disequilibrium (LD), but the impact that recombinational hotspots have on sites linked to selected mutations has not been investigated. We empirically determine chromosomal linkage phase for 5.2 kb spanning the beta -globin gene and hotspot. We estimate that the HbC mutation, which is positively selected because of malaria, originated <5,000 years ago and that selection coefficients are 0.04-0.09. Despite strong selection and the recent origin of the HbC allele, recombination (crossing-over or gene conversion) is observed within 1 kb 5' of the selected site on more than one-third of the HbC chromosomes sampled. The rapid decay in LD upstream of the HbC allele demonstrates the large effect the ss-globin hotspot has in mitigating the effects of positive selection on linked variation.
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