ArticleAmerican journal of human genetics2005
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2007Pooled it
- Circadian rhythm disruption and mental health.Translational psychiatry · 2020Review
- Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.Psychiatric genetics · 2017Article
- TLX-Its Emerging Role for Neurogenesis in Health and Disease.Molecular neurobiology · 2017Review
- Biosynthesis of glycosaminoglycans: associated disorders and biochemical tests.Journal of inherited metabolic disease · 2016Review
- Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder.Translational psychiatry · 2016Article
- Evidence for the role of corticotropin-releasing factor in major depressive disorder.Neuroscience and biobehavioral reviews · 2015Review
- CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis.Psychiatry investigation · 2015Article
- TLX: A master regulator for neural stem cell maintenance and neurogenesis.Biochimica et biophysica acta · 2015Review
- Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.Bipolar disorders · 2014Article
- Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Heritability and linkage analysis of personality in bipolar disorder.Journal of affective disorders · 2013Article
- Questions about DISC1 as a genetic risk factor for schizophrenia.Molecular psychiatry · 2013Article
- Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.Journal of affective disorders · 2013Article
- A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.Journal of affective disorders · 2013Article
- A review of potassium channels in bipolar disorder.Frontiers in genetics · 2013Article
- The association of bipolar spectrum disorders and borderline personality disorder.The Psychiatric quarterly · 2012Review
- Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Genetic association of cyclic AMP signaling genes with bipolar disorder.Translational psychiatry · 2012Article
- Genetic architectures of psychiatric disorders: the emerging picture and its implications.Nature reviews. Genetics · 2012Review
23 more citing papers are in PubMed but not listed here.
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53 authors.
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Abstract
Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficulty and potential pitfalls of the implementation. We conducted a combined analysis using the original genotype data from 11 BP genomewide linkage scans comprising 5,179 individuals from 1,067 families. Heterogeneity among studies was minimized in our analyses by using uniform methods of analysis and a common, standardized marker map and was assessed using novel methods developed for meta-analysis of genome scans. To date, this collaboration is the largest and most comprehensive analysis of linkage samples involving a psychiatric disorder. We demonstrate that combining original genome-scan data is a powerful approach for the elucidation of linkage regions underlying complex disease. Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.