ArticleAmerican journal of human genetics2005
Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
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- Human acrocentric chromosome short armbioRxiv : the preprint server for biology · 2025Article
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- The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation inbioRxiv : the preprint server for biology · 2024Article
- TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.eLife · 2024Article
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- Meiotic Chromosome Dynamics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.Frontiers in cell and developmental biology · 2021Article
- Article
- Preparation of Meiotic Chromosome Spreads from Zebrafish Spermatocytes.Journal of visualized experiments : JoVE · 2020Article
- The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio.PLoS genetics · 2019Article
- Article
- Telomeric TERB1-TRF1 interaction is crucial for male meiosis.Nature structural & molecular biology · 2017Article
- Meiotic behaviour of evolutionary sex-autosome translocations in Bovidae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Article
- Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice.American journal of human genetics · 2016Article
- Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.Nature cell biology · 2015Article
- Article
- Meiotic Recombination: The Essence of Heredity.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The formation of the synaptonemal complex (SC) is a crucial early step in the meiotic process, but relatively little is known about the establishment of the human SC. Accordingly, we recently initiated a study of synapsis in the human male, combining immunofluorescence and fluorescence in situ hybridization methodologies to analyze prophase spermatocytes from a series of control individuals. Our results indicate that synapsis is a tightly regulated process, with relatively little variation among individuals. On nonacrocentric chromosomes, there are two synaptic initiation sites, one on the distal short arm and one on the distal long arm, whereas acrocentric chromosomes exhibit a single site on the distal long arm. For both types of chromosomes, synapsis then proceeds toward the centromere, with little evidence that specific p- or q-arm sequences affect the process. However, the centromere appears to have an inhibitory effect on synapsis--that is, when one arm of a nonacrocentric chromosome is "zippered up" before the other, the centromere acts as a barrier to further movement from that arm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.