Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2006
Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74. Phase II study.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Febrile Neutropenia in Pediatric Cancer Patients by Lactobacillus Rhamnosus GG and Bifidobacterium Animalis Subspecies. Lactis BB-12 in Combination With Inulin and Oligofructose
Prevention of Irinotecan Induced Diarrhea by Probiotics: A Phase III Study
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial.Scientific reports · 2020Trial
- Impact of Probiotics for Reducing Infections in Veterans (IMPROVE): Study protocol for a double-blind, randomized controlled trial to reduce carriage of Staphylococcus aureus.Contemporary clinical trials · 2017Trial
- Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010Trial
- Selenium and probiotics co-supplementation: A scoping review of clinical evidence.Inflammopharmacology · 2026Article
- Intestinal microbiome and myelodysplastic syndromes: Current state of knowledge and perspectives for future.Seminars in hematology · 2024Review
- Bacterial Translocation in Gastrointestinal Cancers and Cancer Treatment.Biomedicines · 2022Review
- The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy.International journal of molecular sciences · 2022Review
- Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review).International journal of oncology · 2021Review
- The Many Faces ofMicroorganisms · 2021Review
- Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies.Microbiome · 2018Review
- Gut microbiota modulation of chemotherapy efficacy and toxicity.Nature reviews. Gastroenterology & hepatology · 2017Review
- Probiotic Survey in Cancer Patients Treated in the Outpatient Department in a Comprehensive Cancer Center.Integrative cancer therapies · 2017Article
- Antimicrobial susceptibility of Enterococcus species isolated from Slovak Bryndza cheese.Folia microbiologica · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Febrile neutropenia (FN) remains a potentially life-threatening complication of anticancer chemotherapy. Bacterial translocation via intestinal mucosa is a significant mechanism of FN development. Competitive inhibition of bowel colonization by pathogenic microorganisms by lactic acid bacteria could be a useful prevention of FN. The aim of the study was the prevention of FN by probiotic strain Enterococcus faecium M-74 enriched with selenium in leukemic patients. Fourteen (six males/eight females) patients with myelogenous leukemia treated by induction or consolidation chemotherapy were included in the study. Patients received prophylaxis with E. faecium M-74 during one cycle of chemotherapy. The daily dose was 36 x 10(9) CFU tid. Prophylaxis started between day -2 and day +2 of chemotherapy and continued until the absolute neutrophile count (ANC) was >1,000/microl. All patients experienced febrile neutropenia. During 231 days of severe neutropenia, 30 febrile episodes occurred. No any febrile episode or infection provoked by the strain tested was noticed. Tolerance of therapy was excellent without significant adverse effects. Our results demonstrate the safety of the probiotic strain E. faecium M-74 enriched with selenium in leukemic patients with severe neutropenia. However, its administration was not effective in the prevention of febrile neutropenia, but this does not preclude the protective effect of other probiotic strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.