Evidence map›Paper›PMID 16175319›Full record

SynthesisJournal of human genetics2005

Ankylosing spondylitis susceptibility loci defined by genome-search meta-analysis.

Young Ho Lee, Young Hee Rho, Seong Jae Choi, Jong Dae Ji, Gwan Gyu Song

Abstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011
    Pooled it
  8. Pooled it
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Young Ho LeeDivision of Rheumatology, Department of Internal Medicine, Medical Center, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, Korea. lyhcgh@korea.ac.kr.
Young Hee RhoDivision of Rheumatology, Department of Internal Medicine, Medical Center, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, Korea.
Seong Jae ChoiDivision of Rheumatology, Department of Internal Medicine, Medical Center, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, Korea.
Jong Dae JiDivision of Rheumatology, Department of Internal Medicine, Medical Center, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, Korea.
Gwan Gyu SongDivision of Rheumatology, Department of Internal Medicine, Medical Center, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In genome scans of ankylosing spondylitis (AS), with the exception of the HLA loci, linkage has not been easy to replicate across studies. We applied the genome-search meta-analysis (GSMA) method to genome scans of AS and spondyloarthropathy (SpA) to assess evidence for linkage across studies. Three AS genome scans and one SpA scan including 430 families with 1,048 affected individuals were used. All four original genome scans mainly analyzed Caucasian families. Seven bins had both Psumrnk and Pord<0.05, suggesting these bins most likely contain AS-linked loci; bin 6.2, 6.1, 6.3, 16.3, 19.2, 17.1, and 16.4. The GSMA produced significant genome-wide evidence for linkage on chromosome 6p22.3-6p21.1 (Psumrnk=0.000003), including the HLA locus. In addition to the HLA-B27 locus, strong linkage evidence was found on chromosome 6p25.3-6p22.3 (Psumrnk=0.0013) and 6p21.1-6p15 (Psumrnk=0.043). In the GSMA of four genome scans including one SpA study, the bin 9.4 (9q21.32-9q33.1) was newly found for linkage (Psumrnk=0.043, Pord=0.013). This GSMA added the evidence of the HLA loci as the greatest susceptibility factor to AS and showed evidences of chromosome 6, 16q, 19, 17p, and 9q as non-HLA susceptibility loci.

Indexed as

Genetic LinkageGenetic Predisposition to DiseaseChromosomes, Human, Pair 6GenomicsHumansSpondylitis, AnkylosingWhite People

Identifiers

PMID16175319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.