ArticleBritish journal of cancer2005
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Phytochemical-Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles.Phytotherapy research : PTR · 2026Review
- HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.Oncology reports · 2024Article
- Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma.Current medical science · 2024Article
- Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway.Frontiers in endocrinology · 2022Article
- Analysis of the bone morphogenetic protein 6 gene promoter region in young beef cattle affected by enzootic bovine leukosis.The Journal of veterinary medical science · 2021Article
- Differential gene expression in skin RNA of horses affected with degenerative suspensory ligament desmitis.Journal of orthopaedic surgery and research · 2020Article
- Expression of bone morphogenetic protein 6 in non-small cell lung cancer and its significance.Oncology letters · 2019Article
- 1,25-Dihydroxyvitamin DOncoTargets and therapy · 2019Article
- Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.International journal of molecular sciences · 2018Review
- The Dual Role of Bone Morphogenetic Proteins in Cancer.Molecular therapy oncolytics · 2018Review
- DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.Cancer cell · 2017Article
- CBX6 overexpression contributes to tumor progression and is predictive of a poor prognosis in hepatocellular carcinoma.Oncotarget · 2017Article
- Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways.BMC cancer · 2016Article
- Regulation of cellular iron metabolism and its implications in lung cancer progression.Medical oncology (Northwood, London, England) · 2014Review
- p38 MAPK regulates the expression of ether à go-go potassium channel in human osteosarcoma cells.Radiology and oncology · 2013Article
- Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer.Oncology letters · 2013Article
- Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.Toxicologic pathology · 2012Article
- Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.Molecular cancer · 2012Article
- Construction of a eukaryotic expression vector pEGFP-C1-BMP-2 and its effect on cell migration.Journal of Zhejiang University. Science. B · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bone morphogenetic proteins (BMPs) are an integral component of the TGFbeta superfamily, responsible for regulation of cell proliferation, differentiation, migration and programmed cell death in a variety of cell types. The BMPs transduce their signals directly through the SMAD family of proteins but they also have been reported to interact with the MAPK and Erk pathways. Inactivation of the BMP pathway genes has been implicated as important in several cancers. Recent work has shown that BMP3b is epigenetically inactivated in cancer and suggests that BMP6 can be epigenetically inactivated. We investigated whether BMP6 is epigenetically inactivated in cell lines and whether BMP3b and BMP6 are epigenetically inactivated in non-small-cell lung cancer (NSCLC). We also studied the relationship between BMP methylation and k-ras mutation. Here, we demonstrate that the BMP3b and BMP6 genes are common targets of epigenetic inactivation in NSCLC, and that they are significantly more likely to be concurrently inactivated (P=0.009). Furthermore, this coinactivation of BMP3b and BMP6 is significantly associated with mutation of k-ras codon 12 in lung cancer (P=0.003); those with a k-ras mutation were six times more likely to have concurrent methylation of these BMP loci. Hence, these data suggest that concurrent inactivation of the BMP and activation of the Ras signalling pathways are important in lung carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.