ReviewNeurocritical care2004
Osmotic therapy: fact and fiction.
Review in Neurocritical care, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03330704 (Randomized Controlled Trial for the Use of Patient Tailored Balanced Hypertonic Solutions in Patients With Cerebral Edema), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial for the Use of Patient Tailored Balanced Hypertonic Solutions in Patients With Cerebral Edema
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- Comparison of equiosmolar hypertonic saline and mannitol for brain relaxation during craniotomies: A meta-analysis of randomized controlled trials.Neurosurgical review · 2018Pooled it
- Agreement of measured and calculated serum osmolality during the infusion of mannitol or hypertonic saline in patients after craniotomy: a prospective, double-blinded, randomised controlled trial.BMC anesthesiology · 2015Trial
- Trial
- Effect of osmotic agents on regional cerebral blood flow in traumatic brain injury.Journal of critical care · 2012Trial
- A noninvasiveAmerican journal of physiology. Endocrinology and metabolism · 2026Article
- Hemorrhagic stroke in children.Journal of central nervous system disease · 2024Review
- Development and verification of a nomogram for predicting short-term mortality in elderly ischemic stroke populations.Scientific reports · 2023Article
- Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2023Review
- Initial Diagnosis and Management of Acutely Elevated Intracranial Pressure.Journal of intensive care medicine · 2023Review
- Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.Frontiers in stroke · 2023Review
- Prediction of long-term mortality in patients with ischemic stroke based on clinical characteristics on the first day of ICU admission: An easy-to-use nomogram.Frontiers in neurology · 2023Article
- Predictive value of the sequential organ failure assessment (SOFA) score for prognosis in patients with severe acute ischemic stroke: a retrospective study.The Journal of international medical research · 2020Article
- What is the Role of Hyperosmolar Therapy in Hemispheric Stroke Patients?Neurocritical care · 2020Review
- Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients.Neurocritical care · 2019Observational
- A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices.IBRO reports · 2017Article
- Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Seizure Disorders in Goats and Sheep.Journal of veterinary internal medicine · 2016Article
- Global cerebral edema from hypercapnic respiratory acidosis and response to hyperosmolar therapy.Neurology · 2016Article
- Renal systems biology of patients with systemic inflammatory response syndrome.Kidney international · 2015Observational
- Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management.World journal of clinical cases · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review examines the available data on the use of osmotic agents in patients with head injury and ischemic stroke, summarizes the physiological effects of osmotic agents, and presents the leading hypotheses regarding the mechanism by which they reduce ICP. Finally, it addresses the validity of the following commonly held beliefs: mannitol accumulates in injured brain; mannitol shrinks only normal brain and can increase midline shift; osmolality can be used to monitor mannitol administration; mannitol should be not be administered if osmolality is >320 mOsm; and hypertonic saline is equally effective as mannitol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.