ArticleProceedings of the National Academy of Sciences of the United States of America2005
Inorganic polyphosphate in the social life of Myxococcus xanthus: motility, development, and predation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polyphosphate Plays a Significant Role in the Maturation of Spores in Myxococcus xanthus.Current microbiology · 2024Article
- Polyphosphate Kinase 2 (PPK2) Enzymes: Structure, Function, and Roles in Bacterial Physiology and Virulence.International journal of molecular sciences · 2022Review
- Model systems for studying polyphosphate biology: a focus on microorganisms.Current genetics · 2021Review
- Did Cyclic Metaphosphates Have a Role in the Origin of Life?Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Review
- Enzymatic Characteristics of a Polyphosphate/ATP-NAD Kinase, PanK, from Myxococcus xanthus.Current microbiology · 2020Article
- Inorganic polyphosphate accumulation suppresses the dormancy response and virulence inThe Journal of biological chemistry · 2019Article
- Catalytic Activity Profile of Polyphosphate Kinase 1 from Myxococcus xanthus.Current microbiology · 2018Article
- Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A new subfamily of polyphosphate kinase 2 (class III PPK2) catalyzes both nucleoside monophosphate phosphorylation and nucleoside diphosphate phosphorylation.Applied and environmental microbiology · 2014Article
- Role of polyphosphate in thermophilic Synechococcus sp. from microbial mats.Journal of bacteriology · 2013Article
- Polyphosphate deficiency in Mycobacterium tuberculosis is associated with enhanced drug susceptibility and impaired growth in guinea pigs.Journal of bacteriology · 2013Article
- New insights into roles of acidocalcisomes and contractile vacuole complex in osmoregulation in protists.International review of cell and molecular biology · 2013Review
- Review
- Regulation of polyphosphate kinase production by antisense RNA in Pseudomonas fluorescens Pf0-1.Applied and environmental microbiology · 2012Article
- Acidocalcisomes.Cell calcium · 2011Review
- Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.Microbial cell factories · 2010Article
- Requirement of polyphosphate by Pseudomonas fluorescens Pf0-1 for competitive fitness and heat tolerance in laboratory media and sterile soil.Applied and environmental microbiology · 2009Article
- Role of polyphosphates in microbial adaptation to extreme environments.Applied and environmental microbiology · 2008Review
- Phosphate acquisition components of the Myxococcus xanthus Pho regulon are regulated by both phosphate availability and development.Journal of bacteriology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic polyphosphate (poly P), a polymer of tens or hundreds of phosphate residues linked by high-energy, ATP-like bonds, is found in all organisms and performs a wide variety of functions. Myxococcus xanthus, a social bacterium that feeds on other bacteria and forms fruiting bodies and spores, depends on poly P for motility, development, and nutritional predation. Two poly P metabolizing enzymes were studied in M. xanthus: poly P kinase 1, which synthesizes poly P reversibly from ATP, and poly P:AMP phosphotransferase, which uses poly P as a donor to also reversibly convert AMP to ADP. The null mutant of ppk1 is defective in social motility, overproduces pilin protein on the cell surface, is delayed in fruiting body formation, produces fewer spores, is delayed in germination, and forms far smaller plaques on a lawn of Klebsiella aerogenes. The pap mutant is also impaired in social motility, but shows only slightly reduced abilities in development and predation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.