Trial reportMolecular psychiatry2005
Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder.
Trial report in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress.American journal of cancer research · 2021Article
- Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.PloS one · 2019Article
- Coupling of microtubule motors with AP-3 generated organelles in axons by NEEP21 family member calcyon.Molecular biology of the cell · 2018Article
- Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California.American journal of epidemiology · 2011Article
- MicroRNA expression profiling reveals miRNA families regulating specific biological pathways in mouse frontal cortex and hippocampus.PloS one · 2011Article
- Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys.Behavioral and brain functions : BBF · 2010Article
- Phylogenetic analysis of the NEEP21/calcyon/P19 family of endocytic proteins: evidence for functional evolution in the vertebrate CNS.Journal of molecular evolution · 2009Article
- Association of attention-deficit/hyperactivity disorder with a candidate region for reading disabilities on chromosome 6p.Biological psychiatry · 2009Article
- Attention-deficit-hyperactivity disorder and reward deficiency syndrome.Neuropsychiatric disease and treatment · 2008Article
- Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma.Neoplasia (New York, N.Y.) · 2008Article
- Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.Behavioural brain research · 2008Article
- Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder.Genes, brain, and behavior · 2008Article
- Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.Journal of psychiatric research · 2008Article
- Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems.Molecular psychiatry · 2007Article
- Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.Behavioral and brain functions : BBF · 2007Article
- No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder.Molecular psychiatry · 2007Article
- Differential effects of a selective dopamine D1-like receptor agonist on motor activity and c-fos expression in the frontal-striatal circuitry of SHR and Wistar-Kyoto rats.Behavioral and brain functions : BBF · 2006Article
- Neurogenetic interactions and aberrant behavioral co-morbidity of attention deficit hyperactivity disorder (ADHD): dispelling myths.Theoretical biology & medical modelling · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attention deficit/hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by marked inattention, hyperactivity and impulsivity. The dopaminergic system has been hypothesized to be involved in the development of ADHD. Positive associations have been found for the dopamine receptors D1 and D5 genes, suggesting that other genes involved in D1/D5 signalling may also contribute to ADHD. In this study, we tested the calcyon gene (DRD1IP), which encodes a brain-specific D1-interacting protein involved in D1/D5 receptors calcium signalling, for association with ADHD. The inheritance of nine polymorphisms in the calcyon gene was examined in a sample of 215 nuclear families, with 260 affected children, using the transmission/disequilibrium test. The most common haplotype, designated C1, demonstrated significant evidence for excess transmission. Quantitative trait analyses of this haplotype showed significant relationships with both the inattentive (parent's rating, P=0.006; teacher's rating, P=0.003) and hyperactive/impulsive (parent's rating, P=0.004) dimensions of the disorder. Two of the nine marker alleles included in haplotype C1, rs4838721A located approximately 10 kb 5' of the gene and rs2275723C located 10 bp upstream of the exon 5 acceptor splice site, also showed significant evidence for association when analysed individually. As these two variants are not predicted to alter calcyon function, we screened the gene exons by sequencing. No variation in the coding region was identified, suggesting that a causal variant allele resides elsewhere in a regulatory sequence of the gene. These findings support the proposed involvement of the calcyon gene in ADHD and implicate haplotype C1 as containing a risk allele.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.