ArticleGenetics2006
Molecular characterization of the major wheat domestication gene Q.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers.
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Who cites it
252 citing papers in PubMed, 615 citations in OpenAlex.
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- Subtle but Significant: Intraspecific Genome Size Variation in Durum Wheat Landraces and Cultivars.Plants (Basel, Switzerland) · 2026Article
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- Histological characteristics, hydrolytic enzyme activity, and changes in plant hormones during the seed-shedding process in two Bromus catharticus Vahl.BMC plant biology · 2026Article
- A regulatory network underlying glume hardness revealed by transcriptomic analysis of an ems-induced mutant in synthetic hexaploid wheat.BMC genomics · 2026Article
- Functional 5Bq allele is responsible for the compact spike phenotype in common wheat (Triticum aestivum L.).BMC plant biology · 2026Article
- Q allele overexpression and alternative splicing can improve wheat yield by increasing thousand-kernel weight and grain number per spike.BMC plant biology · 2026Article
- Image-based rachis phenotyping facilitates genetic dissection of spikelet distribution in wheat.Plant physiology · 2026Article
- Molecular dissection of large-spike trait in wheat revealing stable QTLs and REGULATOR OF GRAIN NUMBER1 as targets for yield improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Physiological and transcriptomic analysis provide new insight into seed shattering mechanism in Carex breviculmis 'Siji'.Plant cell reports · 2025Article
- The impact of asymmetrical gene expression on the development of spike morphology iniMetaOmics · 2025Article
- Impact of Soil Drought on Yield and Leaf Sugar Content in Wheat: Genotypic and Phenotypic Relationships Compared Using a Doubled Haploid Population.International journal of molecular sciences · 2025Article
- Transposable elements drive the subgenomic divergence of homoeologous genes to shape wheat domestication and improvement.Plant communications · 2025Article
- A global assembly of landrace oat (Avena sativa L.) accessions is a discovery resource for adaptive variation, association mapping, and trait deployment.G3 (Bethesda, Md.) · 2025Article
- Population genomics uncovers loci for trait improvement in the indigenous African cereal tef (Eragrostis tef).Communications biology · 2025Article
- Genomic dissection of terminal heat tolerance in synthetic hexaploid derived nested introgression libraries of wheat (Triticum aestivum L.).Functional & integrative genomics · 2025Article
- Identification of robust yield quantitative trait loci derived from cultivated emmer for durum wheat improvement.The plant genome · 2025Article
- Testing the potential of zebularine to induce heritable changes in crop growth and development.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Ancient diversity ofFrontiers in plant science · 2025Article
192 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Q gene is largely responsible for the widespread cultivation of wheat because it confers the free-threshing character. It also pleiotropically influences many other domestication-related traits such as glume shape and tenacity, rachis fragility, spike length, plant height, and spike emergence time. We isolated the Q gene and verified its identity by analysis of knockout mutants and transformation. The Q gene has a high degree of similarity to members of the AP2 family of transcription factors. The Q allele is more abundantly transcribed than q, and the two alleles differ for a single amino acid. An isoleucine at position 329 in the Q protein leads to an abundance of homodimer formation in yeast cells, whereas a valine in the q protein appears to limit homodimer formation. Ectopic expression analysis allowed us to observe both silencing and overexpression effects of Q. Rachis fragility, glume shape, and glume tenacity mimicked the q phenotype in transgenic plants exhibiting post-transcriptional silencing of the transgene and the endogenous Q gene. Variation in spike compactness and plant height were associated with the level of transgene transcription due to the dosage effects of Q. The q allele is the more primitive, and the mutation that gave rise to Q occurred only once leading to the world's cultivated wheats.
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