ArticleGenetics2006
The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Recurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes.Genome biology and evolution · 2025Article
- Paternal Effects in Mammalian Reproduction: Functional, Environmental, and Clinical Relevance of Sperm Components in Early Embryos and Beyond.Molecular reproduction and development · 2025Review
- Schlafens: Emerging Therapeutic Targets.Cancers · 2024Review
- Article
- Structural, molecular, and functional insights into Schlafen proteins.Experimental & molecular medicine · 2022Review
- Article
- Article
- Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.Nature genetics · 2018Article
- Genotypic and phenotypic characterization of the Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model.PloS one · 2018Article
- Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers.G3 (Bethesda, Md.) · 2016Article
- Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.PLoS pathogens · 2016Article
- Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.Molecular and cellular biology · 2015Article
- Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells.Results in immunology · 2015Article
- Schlafen 1 inhibits the proliferation and tube formation of endothelial progenitor cells.PloS one · 2014Article
- Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.The Journal of biological chemistry · 2013Article
- The schlafen family of proteins and their regulation by interferons.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Genetic architecture of skewed X inactivation in the laboratory mouse.PLoS genetics · 2013Article
- Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.The Journal of biological chemistry · 2010Article
- Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross.BMC genetics · 2010Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The DDK syndrome is an early embryonic lethal phenotype observed in crosses between females of the DDK inbred mouse strain and many non-DDK males. Lethality results from an incompatibility between a maternal DDK factor and a non-DDK paternal gene, both of which have been mapped to the Ovum mutant (Om) locus on mouse chromosome 11. Here we define a 465-kb candidate interval for the paternal gene by recombinant progeny testing. To further refine the candidate interval we determined whether males from 17 classical and wild-derived inbred strains are interfertile with DDK females. We conclude that the incompatible paternal allele arose in the Mus musculus domesticus lineage and that incompatible strains should share a common haplotype spanning the paternal gene. We tested for association between paternal allele compatibility/incompatibility and 167 genetic variants located in the candidate interval. Two diallelic SNPs, located in the Schlafen gene cluster, are completely predictive of the polar-lethal phenotype. These SNPs also predict the compatible or incompatible status of males of five additional strains.
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Registered trials
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