ArticleThe Journal of cell biology2005
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Cell adhesion and intracellular calcium signaling in neurons.Cell communication and signaling : CCS · 2013Pooled it
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- Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular CaThe Journal of general physiology · 2019Article
- STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Molecular Analysis of Sensory Axon Branching Unraveled a cGMP-Dependent Signaling Cascade.International journal of molecular sciences · 2018Review
- Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.Neuropharmacology · 2017Article
- Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.Developmental neurobiology · 2017Article
- Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features.Journal of biomedical materials research. Part A · 2016Article
- Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics.Frontiers in cellular neuroscience · 2016Article
- Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Switching responses: spatial and temporal regulators of axon guidance.Molecular neurobiology · 2014Review
- Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.Frontiers in cellular neuroscience · 2014Review
- Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.BMC research notes · 2011Article
- Spatial and temporal second messenger codes for growth cone turning.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal growth cones migrate along the correct paths during development, not only directed by guidance cues but also contacted by local environment via cell adhesion molecules (CAMs). Asymmetric Ca2+ elevations in the growth cone cytosol induce both attractive and repulsive turning in response to the guidance cues (Zheng, J.Q. 2000. Nature. 403:89-93; Henley, J.R., K.H. Huang, D. Wang, and M.M. Poo. 2004. Neuron. 44:909-916). Here, we show that CAMs regulate the activity of ryanodine receptor type 3 (RyR3) via cAMP and protein kinase A in dorsal root ganglion neurons. The activated RyR3 mediates Ca2+-induced Ca2+ release (CICR) into the cytosol, leading to attractive turning of the growth cone. In contrast, the growth cone exhibits repulsion when Ca2+ signals are not accompanied by RyR3-mediated CICR. We also propose that the source of Ca2+ influx, rather than its amplitude or the baseline Ca2+ level, is the primary determinant of the turning direction. In this way, axon-guiding and CAM-derived signals are integrated by RyR3, which serves as a key regulator of growth cone navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.