ArticleEMBO reports2005
Yeast caspase 1 links messenger RNA stability to apoptosis in yeast.
Article in EMBO reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 94 citations in OpenAlex.
- Regulated Cell Death in Fungi, the Role of Metacaspases and Assay Techniques.Methods and protocols · 2026Review
- Calorie Restriction Suppresses Premature Ageing in Pro-Apoptotic Yeast Mutants Through an Autophagy-Independent Mechanism.International journal of molecular sciences · 2026Article
- Yeast Oral Delivery of DAF16 shRNAs Results in Effective Gene Silencing inCurrent issues in molecular biology · 2025Article
- Pilocarpine inhibitsMicrobiology spectrum · 2025Article
- Saccharomyces cerevisiae as a research tool for RNA-mediated human disease.Wiley interdisciplinary reviews. RNA · 2023Review
- Yeast Lsm Pro-Apoptotic Mutants Show Defects in Autophagy.International journal of molecular sciences · 2023Article
- Yeast UPS1 deficiency leads to UVC radiation sensitivity and shortened lifespan.Antonie van Leeuwenhoek · 2023Article
- Neuroserpin Inclusion Bodies in a FENIB Yeast Model.Microorganisms · 2021Article
- Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan.Current microbiology · 2018Article
- Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics.Oxidative medicine and cellular longevity · 2018Review
- Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells.BMC complementary and alternative medicine · 2017Article
- Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants.Apoptosis : an international journal on programmed cell death · 2017Article
- Article
- VDAC regulates AAC-mediated apoptosis and cytochromeMicrobial cell (Graz, Austria) · 2016Article
- External and internal triggers of cell death in yeast.Cellular and molecular life sciences : CMLS · 2016Review
- The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy.Cell death and differentiation · 2014Article
- Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicans.FEMS yeast research · 2014Review
- Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae.PLoS genetics · 2014Article
- Quantification of genetically controlled cell death in budding yeast.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial function and YCA1, which encodes a budding yeast metacaspase, are necessary for apoptosis triggered by stabilization of mRNAs. Deletion of YCA1 in yeast cells mutated in the LSM4 gene prevents mitochondrial fragmentation and rapid cell death during chronological ageing of the culture, diminishes reactive oxygen species accumulation and DNA breakage, and increases resistance to H2O2 and acetic acid. mRNA levels in lsm4 mutants deleted for YCA1 are still increased, positioning the Yca1 budding yeast caspase as a downstream executor of cell death induced by mRNA perturbations. In addition, we show that mitochondrial function is necessary for fast death during chronological ageing, as well as in LSM4 mutated and wild-type cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.