ArticleJournal of neurology, neurosurgery, and psychiatry2005
Clinical spectrum of cryoglobulinaemic neuropathy.
Article in Journal of neurology, neurosurgery, and psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 86 citations in OpenAlex.
- Rituximab in cryoglobulinemic peripheral neuropathy.Journal of neurology · 2009Trial
- Peripheral Neuropathy in Patients with Hepatitis C Infection-Reversibility after HCV Eradication: A Single Center Study.Viruses · 2024Article
- Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections.Frontiers in neurology · 2022Review
- Immunoglobulin M Monoclonal Gammopathies of Clinical Significance.Frontiers in oncology · 2022Review
- Diagnostic and Treatment Considerations in Restless Legs Syndrome Complicated by Diabetic Neuropathy.Current diabetes reports · 2021Review
- Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders.Brain sciences · 2021Review
- Peripheral neuropathy after viral eradication with direct-acting antivirals in chronic HCV hepatitis: A prospective study.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Understanding the Cryoglobulinemias.Current rheumatology reports · 2019Review
- A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.PloS one · 2017Observational
- Rheumatic manifestations of hepatitis C virus chronic infection: Indications for a correct diagnosis.World journal of gastroenterology · 2016Review
- Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview.World journal of gastroenterology · 2015Review
- Extrahepatic immune related manifestations in chronic hepatitis C virus infection.World journal of gastroenterology · 2014Review
- Clinical, neurophysiological, and skin biopsy findings in peripheral neuropathy associated with hepatitis C virus-related cryoglobulinemia.Journal of neurology · 2014Article
- Inflammatory myopathy as the initial presentation of cryoglobulinaemic vasculitis.BMJ case reports · 2013Article
- HCV-related nervous system disorders.Clinical & developmental immunology · 2012Review
- Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy.International archives of medicine · 2008Article
- Molecularly targeted therapies for dysimmune neuropathies.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveCryoglobulinaemic neuropathy (CN) is probably common, as it is usually related to HCV infection. The aim of this study was to delineate the clinical spectrum of CN in a large series and to investigate the factors influencing its expression.
methodsSeventy one consecutive patients (12 men, 59 women), diagnosed as having CN on the basis of clinical features of neuropathy, clinical and serological findings of mixed cryoglobulinaemia, and exclusion criteria, were identified during a six year period. All patients underwent clinical examination, and electrophysiological and laboratory investigations.
resultsResults of the patients with "pure" CN (n = 54) and those with comorbidities (n = 17) were evaluated separately. Of the former 76% had sensory neuropathy (including selective small fibre sensory neuropathy (SFSN) in 14 patients), 15% had sensorimotor polyneuropathy, and 9% had mononeuritis multiplex. The pattern of distribution was similar in the patients with comorbidities. In 30/54 patients, CN was the first manifestation of cryoglobulinaemia. Patients with mild cryoglobulinaemic syndrome had sensory neuropathy more frequently than patients with active syndrome (p < 0.001), in particular SFSN (p < 0.001). The latter group had more severe features, with significantly more cases of reduced or absent motor (p = 0.028) and sensory action potentials (p < 0.001), and a tendency towards higher Rankin scores (p = 0.06).
conclusionsSensory neuropathy, often in the form of SFSN, is by far the commonest form of CN. Cryoglobulinaemia should be vigorously investigated in the diagnosis of sensory neuropathy, especially in older women. Activity of the cryoglobulinaemic syndrome is a major factor influencing the clinical expression and severity of CN.
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