ArticleBiophysical journal2005
Weak effect of membrane diffusion on the rate of receptor accumulation at adhesive contacts.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
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- Allosteric Regulation of E-Cadherin Adhesion.The Journal of biological chemistry · 2015Article
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- Membrane-Bound Catechol-O-Methyl Transferase in Cortical Neurons and Glial Cells is Intracellularly Oriented.Frontiers in psychiatry · 2010Article
- Neurexin/neuroligin interaction kinetics characterized by counting single cell-surface attached quantum dots.Biophysical journal · 2009Article
- Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity.Nature neuroscience · 2009Article
- Article
- Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking.Biophysical journal · 2008Article
- A molecular clutch between the actin flow and N-cadherin adhesions drives growth cone migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Immediate-early signaling induced by E-cadherin engagement and adhesion.The Journal of biological chemistry · 2008Article
- Fast turnover of L1 adhesions in neuronal growth cones involving both surface diffusion and exo/endocytosis of L1 molecules.Molecular biology of the cell · 2007Article
- Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling.Molecular biology of the cell · 2006Article
- Interplay between adhesion turnover and cytoskeleton dynamics in the control of growth cone migration.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess if membrane diffusion could affect the kinetics of receptor recruitment at adhesive contacts, we transfected neurons with green fluorescent protein-tagged immunoglobin cell adhesion molecules of varying length (25-180 kD), and measured the lateral mobility of single quantum dots bound to those receptors at the cell surface. The diffusion coefficient varied within a physiological range (0.1-0.5 microm(2)/s), and was inversely proportional to the size of the receptor. We then triggered adhesive contact formation by placing anti-green fluorescent protein-coated microspheres on growth cones using optical tweezers, and measured surface receptor recruitment around microspheres by time-lapse fluorescence imaging. The accumulation rate was rather insensitive to the type of receptor, suggesting that the long-range membrane diffusion of immunoglobin cell adhesion molecules is not a limiting step in the initiation of neuronal contacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.