ArticleBiophysical journal2005
Mechanical responses of the organ of corti to acoustic and electrical stimulation in vitro.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effect of burst spikes on linear and nonlinear signal transmission in spiking neurons.Journal of computational neuroscience · 2025Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.Communications biology · 2021Article
- Article
- Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.Developmental cell · 2021Article
- Travelling waves and tonotopicity in the inner ear: a historical and comparative perspective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea.Cell reports · 2018Article
- Simulating the Chan-Hudspeth experiment on an active excised cochlear segment.The Journal of the Acoustical Society of America · 2017Article
- Finite-element model of the active organ of Corti.Journal of the Royal Society, Interface · 2016Article
- Article
- Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.PloS one · 2016Article
- Filtering of acoustic signals within the hearing organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Electrokinetic properties of the mammalian tectorial membrane.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- How are inner hair cells stimulated? Evidence for multiple mechanical drives.Hearing research · 2012Article
- Analysis of the cochlear amplifier fluid pump hypothesis.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Article
- Biophysical mechanisms underlying outer hair cell loss associated with a shortened tectorial membrane.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The detection of sound by the cochlea involves a complex mechanical interplay among components of the cochlear partition. An in vitro preparation of the second turn of the jird's cochlea provides an opportunity to measure cochlear responses with subcellular resolution under controlled mechanical, ionic, and electrical conditions that simulate those encountered in vivo. Using photodiode micrometry, laser interferometry, and stroboscopic video microscopy, we have assessed the mechanical responses of the cochlear partition to acoustic and electrical stimuli near the preparation's characteristic frequency. Upon acoustic stimulation, the partition responds principally as a rigid plate pivoting around its insertion along the spiral lamina. The radial motion at the reticular lamina greatly surpasses that of the tectorial membrane, giving rise to shear that deflects the mechanosensitive hair bundles. Electrically evoked mechanical responses are qualitatively dissimilar from their acoustically evoked counterparts and suggest the recruitment of both hair-bundle- and soma-based electromechanical transduction processes. Finally, we observe significant changes in the stiffness of the cochlear partition upon tip-link destruction and tectorial-membrane removal, suggesting that these structures contribute considerably to the system's mechanical impedance and that hair-bundle-based forces can drive active motion of the cochlear partition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.