ArticleThe Journal of experimental biology2005
Identification of sex-specific transcripts of the Anopheles gambiae doublesex gene.
Article in The Journal of experimental biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- An OpIE2-DsRed marker disrupts female blood-feeding and shortens lifespan in the malaria vector Anopheles gambiae.Genetics · 2026Article
- Effects of expressing a maleness gene in Anopheles gambiae cells using baculovirus as a gene delivery tool.Parasites & vectors · 2026Article
- Advancements in CRISPR-Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens.Molecular biotechnology · 2026Review
- A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae.Nature communications · 2025Article
- Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025Review
- Sex-specific transcriptome dynamics ofGenes & development · 2025Article
- First transcriptome analysis of the winter tick (Dermacentor albipictus) reveals sex-specific expression patterns and potential targets for genetic control.G3 (Bethesda, Md.) · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi.Parasites & vectors · 2025Article
- Identification of Sex-Specific and Sex-Biased Transcripts for Genetic Sexing.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso.BMC genomics · 2024Article
- Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi.Infectious diseases of poverty · 2024Article
- Identifying the sex chromosome and sex determination genes in the cattle tick, Rhipicephalus (Boophilus) microplus.G3 (Bethesda, Md.) · 2024Article
- Article
- Targeting Sex Determination to Suppress Mosquito Populations.bioRxiv : the preprint server for biology · 2023Article
- Targeting Sex Determination to Suppress Mosquito Populations.Research square · 2023Article
- A chromosome-level assembly supports genome-wide investigation of the DMRT gene family in the golden mussel (Limnoperna fortunei).GigaScience · 2022Article
- CRISPR/Cas9-Mediated Mutagenesis of Sex-SpecificCells · 2022Article
- CRISPR/Cas9 mediated sex-ratio distortion by sex specific gene editing inSaudi journal of biological sciences · 2022Article
- Effective Oral RNA Interference (RNAi) Administration to Adult Anopheles gambiae Mosquitoes.Journal of visualized experiments : JoVE · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The understanding of the molecular mechanisms of sex differentiation in the mosquito Anopheles gambiae could identify important candidate genes for inducing selective male sterility in transgenic lines or for sex-controlled expression of lethal genes. In many insects, doublesex (dsx) is the double-switch gene at the bottom of the somatic sex-determination cascade that determines the differentiation of sexually dimorphic traits. We report here on the identification of the dsx homologue in A. gambiae and on the characterization of its sex-specific transcripts. Agdsx consists of seven exons, distributed over an 85 kb region on chromosome 2R, which are sex-specifically spliced to produce the female and male AgdsxF and AgdsxM transcripts. AgdsxF contains a 795 bp ORF, coding for a protein of 265 amino acids, while AgdsxM comprises a much longer (1866 bp) ORF, coding for a 622 aa protein. Differences in the exon/intron organization suggest that Agdsx sex-specific splicing results from a different mechanism from Drosophila melanogaster dsx. These findings represent an important step towards the understanding of sex differentiation in Anopheles and will facilitate the use of gene transfer technologies to manipulate sex ratios for vector control programs based on the sterile insect technique.
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