ArticleGenome research2005
Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 214 citations in OpenAlex.
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- The biosynthesis mechanism of bacterioruberin in halophilic archaea revealed by genome and transcriptome analysis.Applied and environmental microbiology · 2024Article
- Protein length distribution is remarkably uniform across the tree of life.Genome biology · 2023Article
- Sec-Dependent Secretion of Subtilase SptE inApplied and environmental microbiology · 2022Article
- Microbial adaptation to different environmental conditions: molecular perspective of evolved genetic and cellular systems.Archives of microbiology · 2022Review
- Net Charges of the Ribosomal Proteins of theMicrobiology spectrum · 2021Article
- Open Issues for Protein Function Assignment inGenes · 2021Article
- Molecular model of a sensor of two-component signaling system.Scientific reports · 2021Article
- Bacterial-like nitric oxide synthase in the haloalkaliphilic archaeon Natronomonas pharaonis.MicrobiologyOpen · 2020Article
- Article
- The Blue-Green Sensory Rhodopsin SRM from Haloarcula marismortui Attenuates Both Phototactic Responses Mediated by Sensory Rhodopsin I and II in Halobacterium salinarum.Scientific reports · 2019Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natronomonas pharaonis is an extremely haloalkaliphilic archaeon that was isolated from salt-saturated lakes of pH 11. We sequenced its 2.6-Mb GC-rich chromosome and two plasmids (131 and 23 kb). Genome analysis suggests that it is adapted to cope with severe ammonia and heavy metal deficiencies that arise at high pH values. A high degree of nutritional self-sufficiency was predicted and confirmed by growth in a minimal medium containing leucine but no other amino acids or vitamins. Genes for a complex III analog of the respiratory chain could not be identified in the N. pharaonis genome, but respiration and oxidative phosphorylation were experimentally proven. These studies identified protons as coupling ion between respiratory chain and ATP synthase, in contrast to other alkaliphiles using sodium instead. Secretome analysis predicts many extracellular proteins with alkaline-resistant lipid anchors, which are predominantly exported through the twin-arginine pathway. In addition, a variety of glycosylated cell surface proteins probably form a protective complex cell envelope. N. pharaonis is fully equipped with archaeal signal transduction and motility genes. Several receptors/transducers signaling to the flagellar motor display novel domain architectures. Clusters of signal transduction genes are rearranged in haloarchaeal genomes, whereas those involved in information processing or energy metabolism show a highly conserved gene order.
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Registered trials
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