ArticleThe Plant cell2005
The RPN1 subunit of the 26S proteasome in Arabidopsis is essential for embryogenesis.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 77 citations in OpenAlex.
- The Radiation Sensitive 23B protein regulates root development partly through the E3 ubiquitin ligase EDA40.Plant cell reports · 2025Article
- Protein degrons and degradation: Exploring substrate recognition and pathway selection in plants.The Plant cell · 2024Review
- Proteasome Dysfunction Leads to Suppression of the Hypoxic Response Pathway in Arabidopsis.International journal of molecular sciences · 2022Article
- Genome-Wide Association Study Reveals Novel QTLs and Candidate Genes for Grain Number in Rice.International journal of molecular sciences · 2022Article
- The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development.The Plant journal : for cell and molecular biology · 2022Article
- RPNs Levels Are Prognostic and Diagnostic Markers for Hepatocellular Carcinoma.Journal of oncology · 2022Article
- The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.Nature communications · 2020Article
- Comparative proteomic and transcriptomic analyses provide new insight into the formation of seed size in castor bean.BMC plant biology · 2020Article
- The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes.Frontiers in plant science · 2020Article
- HSP101 Interacts with the Proteasome and Promotes the Clearance of Ubiquitylated Protein Aggregates.Plant physiology · 2019Article
- Differential proteome analysis during early somatic embryogenesis in Musa spp. AAA cv. Grand Naine.Plant cell reports · 2017Article
- A Novel QTL for Powdery Mildew Resistance in Nordic Spring Barley (Frontiers in plant science · 2017Article
- ahg12 is a dominant proteasome mutant that affects multiple regulatory systems for germination of Arabidopsis.Scientific reports · 2016Article
- Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling.Nature communications · 2016Article
- Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of African rice.Nature genetics · 2015Article
- AtPGL3 is an Arabidopsis BURP domain protein that is localized to the cell wall and promotes cell enlargement.Frontiers in plant science · 2015Article
- Chloroplast dysfunction causes multiple defects in cell cycle progression in the Arabidopsis crumpled leaf mutant.Plant physiology · 2014Article
- Protein abundance changes and ubiquitylation targets identified after inhibition of the proteasome with syringolin A.Molecular & cellular proteomics : MCP · 2014Article
- From callus to embryo: a proteomic view on the development and maturation of somatic embryos in Cyclamen persicum.Planta · 2012Article
- The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis.The Plant cell · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 26S proteasome plays a central role in the degradation of regulatory proteins involved in a variety of developmental processes. It consists of two multisubunit protein complexes: the proteolytic core protease and the regulatory particle (RP). The function of most RP subunits is poorly understood. Here, we describe mutants in the Arabidopsis thaliana RPN1 subunit, which is encoded by two paralogous genes, RPN1a and RPN1b. Disruption of RPN1a caused embryo lethality, while RPN1b mutants showed no obvious abnormal phenotype. Embryos homozygous for rpn1a arrested at the globular stage with defects in the formation of the embryonic root, the protoderm, and procambium. Cyclin B1 protein was not degraded in these embryos, consistent with cell division defects. Double mutant plants (rpn1a/RPN1a rpn1b/rpn1b) produced embryos with a phenotype indistinguishable from that of the rpn1a single mutant. Thus, despite their largely overlapping expression patterns in flowers and developing seeds, the two isoforms do not share redundant functions during gametogenesis and embryogenesis. However, complementation of the rpn1a mutation with the coding region of RPN1b expressed under the control of the RPN1a promoter indicates that the two RPN1 isoforms are functionally equivalent. Overall, our data indicate that RPN1 activity is essential during embryogenesis, where it might participate in the destruction of a specific set of protein substrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.