Evidence map›Paper›PMID 16168092›Full record

ReviewGenome biology2005

Canonical Wnt signaling: high-throughput RNAi widens the path.

Anthony M C Brown

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. MicroRNA-322 Regulates Self-renewal of Mouse Spermatogonial Stem Cells throughInternational journal of biological sciences · 2019
    Article
  4. Article
  5. Defining the cancer master switch.World journal of surgery · 2011
    Review
  6. Article
  7. Genomic screening with RNAi: results and challenges.Annual review of biochemistry · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Anthony M C BrownDepartment of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Prevention Center, New York, NY 10021, USA. amcbrown@med.cornell.edu

Funding

Wnt signaling in mammary development and cancerR01CA047207 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1996 to 2006
$2.0M
ACTION OF THE ONCOGENE INT-1 IN MAMMARY TUMORSR29CA047207 · NCI · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1988 to 1992
–
NCI NIH HHS CA47207NCI NIH HHS R01 CA047207
6 · The paper itself

Abstract

The canonical Wnt signaling pathway is highly conserved in evolution, widely used throughout animal development, and frequently hyperactive in cancer. Although Wnt signaling has been the subject of extensive genetic analysis in the past, some 200 genes have now been identified as candidate modulators of this pathway by a recent study using high-throughput RNAi screening.

Indexed as

RNA InterferenceSignal TransductionAnimalsbeta CateninDrosophila melanogasterHumansWnt Proteinsbeta CateninWnt Proteins

Identifiers

PMID16168092
PMCPMC1242201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.