ArticleGenome biology2005
Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae.
Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92 citing papers in PubMed, 219 citations in OpenAlex.
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- Evolution of cross-tolerance to metals in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Adaptation to a limiting element involves mitigation of multiple elemental imbalances.Journal of the Royal Society, Interface · 2023Article
- Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells ofFrontiers in physiology · 2023Article
- Drought specifically downregulates mineral nutrition: Plant ionomic content and associated gene expression.Plant direct · 2022Article
- The mouse metallomic landscape of aging and metabolism.Nature communications · 2022Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
- Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro.The Journal of biological chemistry · 2021Article
- IonFlow: a galaxy tool for the analysis of ionomics data sets.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Exploring metal ion metabolisms to improve xylose fermentation in Saccharomyces cerevisiae.Microbial biotechnology · 2021Article
- Genetic architecture of root and shoot ionomes in rice (Oryza sativa L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Ascorbic acid mitigates cadmium-induced stress, and contributes to ionome stabilization in fission yeast.Environmental science and pollution research international · 2021Article
- Depletion of Boric Acid and Cobalt from Cultivation Media: Impact on Recombinant Protein Production withBioengineering (Basel, Switzerland) · 2020Article
- Mutations in the V-ATPase Assembly Factor VMA21 Cause a Congenital Disorder of Glycosylation With Autophagic Liver Disease.Hepatology (Baltimore, Md.) · 2020Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNutrient minerals are essential yet potentially toxic, and homeostatic mechanisms are required to regulate their intracellular levels. We describe here a genome-wide screen for genes involved in the homeostasis of minerals in Saccharomyces cerevisiae. Using inductively coupled plasma-atomic emission spectroscopy (ICP-AES), we assayed 4,385 mutant strains for the accumulation of 13 elements (calcium, cobalt, copper, iron, potassium, magnesium, manganese, nickel, phosphorus, selenium, sodium, sulfur, and zinc). We refer to the resulting accumulation profile as the yeast 'ionome'.
resultsWe identified 212 strains that showed altered ionome profiles when grown on a rich growth medium. Surprisingly few of these mutants (four strains) were affected for only one element. Rather, levels of multiple elements were altered in most mutants. It was also remarkable that only six genes previously shown to be involved in the uptake and utilization of minerals were identified here, indicating that homeostasis is robust under these replete conditions. Many mutants identified affected either mitochondrial or vacuolar function and these groups showed similar effects on the accumulation of many different elements. In addition, intriguing positive and negative correlations among different elements were observed. Finally, ionome profile data allowed us to correctly predict a function for a previously uncharacterized gene, YDR065W. We show that this gene is required for vacuolar acidification.
conclusionOur results indicate the power of ionomics to identify new aspects of mineral homeostasis and how these data can be used to develop hypotheses regarding the functions of previously uncharacterized genes.
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