ArticleGenome biology2005
Differential gene expression in anatomical compartments of the human eye.
Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.Nature genetics · 2012Pooled it
- Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration.Molecular vision · 2012Pooled it
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- Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults.Human genomics · 2024Article
- Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease.Journal of virology · 2022Article
- Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosa.Stem cell research & therapy · 2022Article
- Prioritization of regulatory variants with tissue-specific function in the non-coding regions of human genome.Nucleic acids research · 2022Article
- Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye.Experimental eye research · 2021Article
- Molecular characteristics and spatial distribution of adult human corneal cell subtypes.Scientific reports · 2021Article
- Humic-acid-driven escape from eye parasites revealed by RNA-seq and target-specific metabarcoding.Parasites & vectors · 2020Article
- Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Major review: Molecular genetics of primary open-angle glaucoma.Experimental eye research · 2017Review
- Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.Human molecular genetics · 2016Article
- Article
- Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Article
- Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq.Experimental eye research · 2014Article
- Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa.Molecular vision · 2014Article
- Exploration of molecular factors impairing superoxide dismutase isoforms activity in human senile cataractous lenses.Investigative ophthalmology & visual science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe human eye is composed of multiple compartments, diverse in form, function, and embryologic origin, that work in concert to provide us with our sense of sight. We set out to systematically characterize the global gene expression patterns that specify the distinctive characteristics of the various eye compartments.
resultsWe used DNA microarrays representing approximately 30,000 human genes to analyze gene expression in the cornea, lens, iris, ciliary body, retina, and optic nerve. The distinctive patterns of expression in each compartment could be interpreted in relation to the physiology and cellular composition of each tissue. Notably, the sets of genes selectively expressed in the retina and in the lens were particularly large and diverse. Genes with roles in immune defense, particularly complement components, were expressed at especially high levels in the anterior segment tissues. We also found consistent differences between the gene expression patterns of the macula and peripheral retina, paralleling the differences in cell layer densities between these regions. Based on the hypothesis that genes responsible for diseases that affect a particular eye compartment are likely to be selectively expressed in that compartment, we compared our gene expression signatures with genetic mapping studies to identify candidate genes for diseases affecting the cornea, lens, and retina.
conclusionThrough genome-scale gene expression profiling, we were able to discover distinct gene expression 'signatures' for each eye compartment and identified candidate disease genes that can serve as a reference database for investigating the physiology and pathophysiology of the eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.