ReviewJournal of bioenergetics and biomembranes2005
Cytoprotective channels in mitochondria.
Review in Journal of bioenergetics and biomembranes, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Hypoxia-Inducible Factor-1Oxidative medicine and cellular longevity · 2019Article
- Physiology of potassium channels in the inner membrane of mitochondria.Pflugers Archiv : European journal of physiology · 2012Review
- Single channel studies of the ATP-regulated potassium channel in brain mitochondria.Journal of bioenergetics and biomembranes · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several ion channels are expressed in the inner and outer membranes of mitochondria, but the exact function of these channels is not completely understood. The opening of certain channels is thought to induce the process of cell death or apoptosis. However, other channels of the inner mitochondrial membrane help protect against ischemic injury and oxidative stress. Mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)) and mitochondrial Ca(2+)-activated K(+) channels (mitoK(Ca)) are the primary protective channels that have been identified. In addition to their thermogenic role, certain isoforms of uncoupling proteins are also shown to have protective roles in certain experimental models. This review attempts to provide an updated overview of the proposed mechanism for the protective function of these membrane proteins. Controversies and unanswered questions regarding these channels will also be discussed.
Indexed as
Identifiers
16167174What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.