ArticleMolecular and cellular biology2005
Modulation of yeast genome expression in response to defective RNA polymerase III-dependent transcription.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Regulatory networking of the three RNA polymerases helps the eukaryotic cells cope with environmental stress.Current genetics · 2021Review
- Reprogramming mRNA Expression in Response to Defect in RNA Polymerase III Assembly in the YeastInternational journal of molecular sciences · 2021Article
- CiBER-seq dissects genetic networks by quantitative CRISPRi profiling of expression phenotypes.Science (New York, N.Y.) · 2020Article
- BRF Negatively Regulates Thermotolerance Defect ofFrontiers in plant science · 2020Article
- Glycolytic flux inThe Biochemical journal · 2019Article
- Is the cellular initiation of translation an exclusive property of the initiator tRNAs?RNA biology · 2015Article
- Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae.BMC biology · 2014Article
- Intergenic transcriptional interference is blocked by RNA polymerase III transcription factor TFIIIB in Saccharomyces cerevisiae.Genetics · 2014Article
- Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC.The Journal of biological chemistry · 2013Article
- Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells.PLoS genetics · 2012Article
- Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing.The Journal of biological chemistry · 2011Article
- Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA(fMet) selection on the ribosomal P-site in Escherichia coli.Nucleic acids research · 2011Article
- TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae.Eukaryotic cell · 2008Article
- Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription.Molecular and cellular biology · 2007Article
- Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.PLoS biology · 2007Article
- An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1.PloS one · 2007Article
- A tDNA establishes cohesion of a neighboring silent chromatin domain.Genes & development · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used genome-wide expression analysis in Saccharomyces cerevisiae to explore whether and how the expression of protein-coding, RNA polymerase (Pol) II-transcribed genes is influenced by a decrease in RNA Pol III-dependent transcription. The Pol II transcriptome was characterized in four thermosensitive, slow-growth mutants affected in different components of the RNA Pol III transcription machinery. Unexpectedly, we found only a modest correlation between altered expression of Pol II-transcribed genes and their proximity to class III genes, a result also confirmed by the analysis of single tRNA gene deletants. Instead, the transcriptome of all of the four mutants was characterized by increased expression of genes known to be under the control of the Gcn4p transcriptional activator. Indeed, GCN4 was found to be translationally induced in the mutants, and deleting the GCN4 gene eliminated the response. The Gcn4p-dependent expression changes did not require the Gcn2 protein kinase and could be specifically counteracted by an increased gene dosage of initiator tRNA(Met). Initiator tRNA(Met) depletion thus triggers a GCN4-dependent reprogramming of genome expression in response to decreased Pol III transcription. Such an effect might represent a key element in the coordinated transcriptional response of yeast cells to environmental changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.