ArticleMolecular and cellular biology2005
Translation initiation factor 4E inhibits differentiation of erythroid progenitors.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment.Nature reviews. Cancer · 2023Review
- Regulation of eIF4E guides a unique translational program to control erythroid maturation.Science advances · 2022Article
- mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.Scientific reports · 2019Article
- Article
- RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis.Frontiers in physiology · 2018Review
- Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors.PloS one · 2018Article
- Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.PloS one · 2014Article
- Expression of different functional isoforms in haematopoiesis.International journal of hematology · 2014Review
- The role of translation initiation regulation in haematopoiesis.Comparative and functional genomics · 2012Article
- Diamond Blackfan anemia treatment: past, present, and future.Seminars in hematology · 2011Review
- Review
- Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and inducing apoptosis of endothelial progenitor cells.Texas Heart Institute journal · 2010Article
- Let-7 microRNAs are developmentally regulated in circulating human erythroid cells.Journal of translational medicine · 2009Article
- Role of stem cell factor in the reactivation of human fetal hemoglobin.Mediterranean journal of hematology and infectious diseases · 2009Article
- Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2.Immunology · 2009Article
- Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments.RNA (New York, N.Y.) · 2007Article
- EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation.BMC cell biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell factor (SCF) delays differentiation and enhances the expansion of erythroid progenitors. Previously, we performed expression-profiling experiments to link signaling pathways to target genes using polysome-bound mRNA. SCF-induced phosphoinositide-3-kinase (PI3K) appeared to control polysome recruitment of specific mRNAs associated with neoplastic transformation. To evaluate the role of mRNA translation in the regulation of expansion versus differentiation of erythroid progenitors, we examined the function of the eukaryote initiation factor 4E (eIF4E) in these cells. SCF induced a rapid and complete phosphorylation of eIF4E-binding protein (4E-BP). Overexpression of eIF4E did not induce factor-independent growth but specifically impaired differentiation into mature erythrocytes. Overexpression of eIF4E rendered polysome recruitment of mRNAs with structured 5' untranslated regions largely independent of growth factor and resistant to the PI3K inhibitor LY294002. In addition, overexpression of eIF4E rendered progenitors insensitive to the differentiation-inducing effect of LY294002, indicating that control of mRNA translation is a major pathway downstream of PI3K in the regulation of progenitor expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.