ArticleJournal of bacteriology2005
The H2O2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The Surfactin-Like Lipopeptides FromFrontiers in bioengineering and biotechnology · 2021Pooled it
- Research advances in the identification of regulatory mechanisms of surfactin production by Bacillus: a review.Microbial cell factories · 2024Review
- A review on surfactin: molecular regulation of biosynthesis.Archives of microbiology · 2023Review
- Chemical structure, properties and potential applications of surfactin, as well as advanced strategies for improving its microbial production.AIMS microbiology · 2023Review
- Development of a novel expression system in lactic acid bacteria controlled by a broad-host-range promoter PMicrobial cell factories · 2022Article
- Bacillus sp.: A Remarkable Source of Bioactive Lipopeptides.Advances in biochemical engineering/biotechnology · 2022Article
- Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of themBio · 2021Article
- The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.PLoS pathogens · 2021Article
- Constructing ofInternational journal of molecular sciences · 2021Article
- Bacterial Response to Oxidative Stress and RNA Oxidation.Frontiers in genetics · 2021Review
- TheGenes · 2020Article
- Genetic variants of the oppA gene are involved in metabolic regulation of surfactin in Bacillus subtilis.Microbial cell factories · 2019Article
- Rational strain improvement for surfactin production: enhancing the yield and generating novel structures.Microbial cell factories · 2019Review
- Roles and regulation of Spx family transcription factors in Bacillus subtilis and related species.Advances in microbial physiology · 2019Review
- Pirated Siderophores Promote Sporulation in Bacillus subtilis.Applied and environmental microbiology · 2017Article
- Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45.Scientific reports · 2017Article
- Article
- Mechanisms of group A Streptococcus resistance to reactive oxygen species.FEMS microbiology reviews · 2015Review
- Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in Bacillus subtilis.Journal of industrial microbiology & biotechnology · 2015Article
- Bacterial transformation: distribution, shared mechanisms and divergent control.Nature reviews. Microbiology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
srfA is an operon required for the synthesis of surfactin and the development of genetic competence in Bacillus subtilis. We observed that the expression of srfA is downregulated upon treatment with H2O2. Thus, we examined the involvement of several oxidative stress-responsive transcription factors in srfA expression. Our DNA microarray analysis revealed that the H2O2 stress-responsive regulator PerR is required for srfA expression. This was confirmed by lacZ fusion analysis. A ComX feeding assay and epistatic analyses revealed that the role of PerR in srfA expression is independent of other known regulators of srfA expression, namely, comQXP, rapC, and spx. Gel mobility shift and footprint assays revealed that PerR binds directly to two tandemly arranged noncanonical PerR boxes located in the upstream promoter region of srfA. A transcriptional srfA-lacZ fusion lacking both PerR boxes showed diminished and PerR-independent expression, indicating that the PerR boxes we identified function as positive cis elements for srfA transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.