ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2005
Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00279682 (Prevention of Suicide in Primary Care Elderly), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Suicide in Primary Care Elderly: Collaborative Trial
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.JAMA psychiatry · 2015Pooled it
- Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review.General hospital psychiatryPooled it
- Trial
- Usefulness of mirtazapine and SSRIs in late-life depression: post hoc analysis of the GUNDAM study.European journal of clinical pharmacology · 2023Trial
- Improving Mental Health Treatment Initiation among Depressed Community Dwelling Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Trial
- Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.Contemporary clinical trials · 2015Trial
- Feasibility of integrating mental health screening and services into routine elder abuse practice to improve client outcomes.Journal of elder abuse & neglect · 2015Trial
- The wish to die and 5-year mortality in elderly primary care patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2010Trial
- Disparity in use of psychotherapy offered in primary care between older african-american and white adults: results from a practice-based depression intervention trial.Journal of the American Geriatrics Society · 2010Trial
- Achieving effective antidepressant pharmacotherapy in primary care: the role of depression care management in treating late-life depression.Journal of the American Geriatrics Society · 2009Trial
- Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT).Diabetes care · 2007Trial
- The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial.Annals of internal medicine · 2007Trial
- Integration of depression and hypertension treatment: a pilot, randomized controlled trial.Annals of family medicineTrial
- Indicators of mortality risk in ageing horses.GeroScience · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Machine learning algorithms to predict depression in older adults in China: a cross-sectional study.Frontiers in public health · 2024Article
- Centering Culture in Mental Health: Differences in Diagnosis, Treatment, and Access to Care Among Older People of Color.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Review
- Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation.Scientific reports · 2022Article
- The role of disability and depressive symptoms in the relation between objective cognitive performance and subjective cognitive decline.Frontiers in psychiatry · 2022Article
- Community delivery of brief therapy for depressed older adults impacted by Hurricane Sandy.Translational behavioral medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveDepression is a major contributor to death and disability, but few follow-up studies of depression have been carried out in the primary-care setting. The authors sought to assess whether depression in older patients is associated with increased mortality after a 2-year follow-up interval and to estimate the population-attributable fraction (PAF) of depression on mortality in older primary-care patients.
methodsLongitudinal cohort analysis was carried out in 20 primary-care practices. Participants were identified though a two-stage, age-stratified (60-74 or 75+) depression screening of randomly sampled patients; enrollment included patients who screened positive and a random sample of screened-negative patients. In all, 1,226 persons were assessed at baseline. Vital status at 2 years was the outcome of interest.
resultsOf 1,226 persons in the sample, 598 were classified as depressed. After 2 years, 64 persons had died. Persons with depression at baseline were more likely to die at the end of the 2-year follow-up interval than were persons without depression, even after accounting for potentially influential covariates such as whether the participant reported a history of myocardial infarction (MI) or diabetes.
conclusionsAmong older, primary-care patients over the course of a 2-year follow-up interval, depression contributed as much to mortality as did MI or diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.