ArticleGenes & development2005
The bromodomain protein GTE6 controls leaf development in Arabidopsis by histone acetylation at ASYMMETRIC LEAVES1.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 83 citations in OpenAlex.
- Nutrient-driven TOR signalling controls a chromatin-associated complex for orchestrating plant growth and stress tolerance.Nature plants · 2025Article
- Bromodomain-containing proteins interact with a non-canonical RNA polymerase II kinase to maintain gene expression upon heat stress.Nature plants · 2025Article
- The GTE4-EML chromatin reader complex concurrently recognizes histone acetylation and H3K4 trimethylation in Arabidopsis.The Plant cell · 2024Article
- Insights into the genetic architecture of the reciprocal interspecific hybrids derived fromMolecular breeding : new strategies in plant improvement · 2024Article
- Spotlight on Plant Bromodomain Proteins.Biology · 2023Review
- Genome-wide analysis of bromodomain gene family in Arabidopsis and rice.Frontiers in plant science · 2023Article
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- Genome-Wide Analysis of the MYB Transcription Factor Superfamily inInternational journal of molecular sciences · 2020Article
- Identification of QTLs for Domestication-Related Traits in Zombi Pea [Frontiers in genetics · 2020Article
- ETR1/RDO3 Regulates Seed Dormancy by Relieving the Inhibitory Effect of the ERF12-TPL Complex onThe Plant cell · 2019Article
- Bromodomain proteins GTE9 and GTE11 are essential for specific BT2-mediated sugar and ABA responses in Arabidopsis thaliana.Plant molecular biology · 2018Article
- Ethylene induces combinatorial effects of histone H3 acetylation in gene expression in Arabidopsis.BMC genomics · 2017Article
- Arabidopsis seed germination speed is controlled by SNL histone deacetylase-binding factor-mediated regulation of AUX1.Nature communications · 2016Article
- The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing.Nature communications · 2016Article
- AtHD2D Gene Plays a Role in Plant Growth, Development, and Response to Abiotic Stresses in Arabidopsis thaliana.Frontiers in plant science · 2016Article
- SWP73 Subunits of Arabidopsis SWI/SNF Chromatin Remodeling Complexes Play Distinct Roles in Leaf and Flower Development.The Plant cell · 2015Article
- Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12.Molecules and cells · 2015Article
- Polycomb-mediated gene silencing in Arabidopsis thaliana.Molecules and cells · 2014Review
- Genome-wide identification of long noncoding natural antisense transcripts and their responses to light in Arabidopsis.Genome research · 2014Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The transition from the juvenile to the mature phase during vegetative development in plants is characterized by changes in leaf shape. We show that GENERAL TRANSCRIPTION FACTOR GROUP E6 (GTE6) regulates differences in leaf patterning between juvenile and mature leaves in Arabidopsis. GTE6 encodes a novel small bromodomain-containing protein unique to plants. Mutations in GTE6 disrupt the formation of elliptical leaf laminae in mature leaves, whereas overexpression of GTE6 resulted in elongated juvenile leaves. GTE6 positively regulates the expression of ASYMMETRIC LEAVES1 (AS1), which encodes a myb-domain protein that controls proximodistal patterning of leaves. Using chromatin immunoprecipitation (ChIP) assays, we show that GTE6 is associated with the promoter and the start of the transcribed region of AS1 and up-regulates expression of AS1 through acetylation of histones H3 and H4. Genetic studies demonstrated that AS1 is epistatic to GTE6, indicating that GTE6 regulates AS1 during leaf morphogenesis. Chromatin remodeling at AS1 is a key regulatory mechanism in leaf development, which ensures the continual production of mature leaves following juvenile-adult transition, thereby maintaining the identity of the mature vegetative phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.