ArticleGenes & development2005
The global regulator H-NS acts directly on the transpososome to promote Tn10 transposition.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- H-NS is a bacterial transposon capture protein.Nature communications · 2024Article
- Article
- Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells.PLoS genetics · 2014Article
- Identification of basepairs within Tn5 termini that are critical sfor H-NS binding to the transpososome and regulation of Tn5 transposition.Mobile DNA · 2012Article
- H-NS mediates the dissociation of a refractory protein-DNA complex during Tn10/IS10 transposition.Nucleic acids research · 2011Article
- Learning to live together: mutualism between self-splicing introns and their hosts.BMC biology · 2011Review
- Intrinsic characteristics of neighboring DNA modulate transposable element activity in Drosophila melanogaster.Genetics · 2011Article
- Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein.Nucleic acids research · 2010Article
- Physiological and transcriptional response of Lactobacillus casei ATCC 334 to acid stress.Journal of bacteriology · 2010Article
- Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences.Genetica · 2010Review
- H-NS binds with high affinity to the Tn10 transpososome and promotes transpososome stabilization.Nucleic acids research · 2009Article
- The SET complex acts as a barrier to autointegration of HIV-1.PLoS pathogens · 2009Article
- The global bacterial regulator H-NS promotes transpososome formation and transposition in the Tn5 system.Nucleic acids research · 2009Article
- Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap.Journal of virology · 2006Article
- Mutation as a stress response and the regulation of evolvability.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The histone-like nucleoid structuring (H-NS) protein is a global transcriptional regulator that is known to regulate stress response pathways and virulence genes in bacteria. It has also been implicated in the regulation of bacterial transposition systems, including Tn10. We demonstrate here that H-NS promotes Tn10 transposition by binding directly to the transposition complex (or transpososome). We present evidence that, upon binding, H-NS induces the unfolding of the Tn10 transpososome and helps to maintain the transpososome in an unfolded state. This ensures that intermolecular (as opposed to self-destructive intramolecular) transposition events are favored. We present evidence that H-NS binding to the flanking donor DNA of the transpososome is the initiating event in the unfolding process. We propose that by recruiting H-NS as a modulator of transposition, Tn10 has evolved a means of sensing changes in host physiology, as the amount of H-NS in the cell, as well its activity, are responsive to changes in environmental conditions. Sensing of environmental changes through H-NS would allow transposition to occur when it is most opportune for both the transposon and the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.