ArticleCancer research2005
Tumor necrosis factor-related apoptosis-inducing ligand alters mitochondrial membrane lipids.
Article in Cancer research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Advances in Polymer Micelles for Cancer Therapy: From Conventional to Smart Delivery Systems.Pharmaceutics · 2026Review
- Phospholipid scramblase 3: a latent mediator connecting mitochondria and heavy metal apoptosis.Cell biochemistry and biophysics · 2023Article
- Fucosylated oligosaccharide Lacto-Food chemistry: X · 2022Article
- BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.Cell death & disease · 2019Article
- Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation.Autophagy · 2014Article
- Understanding the conservation patterns and molecular phylogenetics of human death receptors family through computational biology.3 Biotech · 2014Article
- Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Immunomodulation by different types of N-oxides in the hemocytes of the marine bivalve Mytilus galloprovincialis.PloS one · 2012Article
- Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process.The Journal of biological chemistry · 2011Article
- Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome.The Journal of biological chemistry · 2011Article
- Multivariate statistical differentiation of renal cell carcinomas based on lipidomic analysis by ambient ionization imaging mass spectrometry.Analytical and bioanalytical chemistry · 2010Article
- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.Apoptosis : an international journal on programmed cell death · 2008Article
- Death receptor ligation triggers membrane scrambling between Golgi and mitochondria.Cell death and differentiation · 2007Article
- Down-regulation of phospholipase D2 mRNA in neonatal rat brainstem and cerebellum after hypoxia-ischemia.Neurochemical research · 2006Article
- Mitochondria as therapeutic targets for cancer chemotherapy.Oncogene · 2006Review
- Following the TRAIL to apoptosis.Immunologic research · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to have selective antitumor activity. TRAIL induces ubiquitous pathways of cell death in which caspase activation is mediated either directly or via the release of apoptogenic factors from mitochondria; however, the precise components of the mitochondrial signaling pathway have not been well defined. Notably, mitochondria constitute an important target in overcoming resistance to TRAIL in many types of tumors. Bid is considered to be fundamental in engaging mitochondria during death receptor-mediated apoptosis, but this action is dependent on mitochondrial lipids. Here, we report that TRAIL signaling induces an alteration in mitochondrial membrane lipids, particularly cardiolipin. This occurs independently of caspase activation and primes mitochondrial membranes to the proapoptotic action of Bid. We unveil a link between TRAIL signaling and alteration of membrane lipid homeostasis that occurs in parallel to apical caspase activation but does not take over the mode of cell death because of the concurrent activation of caspase-8. In particular, TRAIL-induced alteration of mitochondrial lipids follows an imbalance in the cellular homeostasis of phosphatidylcholine, which results in an elevation in diacylglycerol (DAG). Elevated DAG in turn activates the delta isoform of phospholipid-dependent serine/threonine protein kinase C, which then accelerates the cleavage of caspase-8. We also show that preservation of phosphatidylcholine homeostasis by inhibition of lipid-degrading enzymes almost completely impedes the activation of pro-caspase-9 while scarcely changing the activation of caspase-8.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.