ArticlePsychopharmacology2005
D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology.International journal of molecular sciences · 2023Review
- Modulation of CaBMC research notes · 2018Article
- Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats.PloS one · 2017Article
- Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels.PloS one · 2015Article
- D2-like receptor activation does not initiate a brain docosahexaenoic acid signal in unanesthetized rats.BMC neuroscience · 2014Article
- Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability.Journal of neurochemistry · 2013Article
- Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.European journal of pharmacology · 2012Article
- Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse.The International journal of neuroscience · 2012Article
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Brain research bulletin · 2012Review
- Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.Neuropharmacology · 2011Article
- Cognition, dopamine and bioactive lipids in schizophrenia.Frontiers in bioscience (Scholar edition) · 2011Review
- Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson disease.Neurochemical research · 2010Article
- Bipolar disorder and mechanisms of action of mood stabilizers.Brain research reviews · 2009Review
- Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids.Biochimica et biophysica acta · 2009Review
- Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.The international journal of neuropsychopharmacology · 2009Article
- Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2009Article
- Chronic d-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain.The international journal of neuropsychopharmacology · 2008Article
- Chronic carbamazepine administration attenuates dopamine D2-like receptor-initiated signaling via arachidonic acid in rat brain.Neurochemical research · 2008Article
- Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?Molecular psychiatry · 2008Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesSignal transduction involving the activation of phospholipase A2 (PLA2) to release arachidonic acid (AA) from membrane phospholipids, when coupled to dopamine D1- and D2-type receptors, can be imaged in rats having a chronic unilateral lesion of the substantia nigra. It is not known, however, if the signaling responses occur in the absence of a lesion. To determine this, we used our in vivo fatty acid method to measure signaling in response to D1 and D2 receptor agonists given acutely to unanesthetized rats.
methods[1-(14)C]AA was injected intravenously in unanesthetized rats, and incorporation coefficients k* for AA (brain radioactivity/integrated plasma radioactivity) were measured using quantitative autoradiography in 61 brain regions. The animals were administered i.v. the D2 receptor agonist, quinpirole (1 mg kg(-1), i.v.), the D1 receptor agonist SKF-38393 (5 mg kg(-1), i.v.), or vehicle/saline.
resultsQuinpirole increased k* significantly in multiple brain regions rich in D2-type receptors, whereas SKF-38393 did not change k* significantly in any of the 61 regions examined.
conclusionsIn the intact rat brain, D2 but not D1 receptors are coupled to the activation of PLA2 and the release of AA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.