ArticleAnnals of the rheumatic diseases1992
Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum.
Article in Annals of the rheumatic diseases, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Peripheral biomarkers of neuronal damage in neuropsychiatric systemic lupus erythematosus (NPSLE).Frontiers in cellular neuroscience · 2026Review
- Cardiolipin Antibody: A Potential Biomarker for Depression.Journal of personalized medicine · 2022Article
- Neurological and Neuropsychiatric Manifestations of Antiphospholipid-Antibody Syndrome (APS).Cureus · 2022Review
- Antiphospholipid Antibodies Overlapping in Isolated Neurological Syndrome and Multiple Sclerosis: Neurobiological Insights and Diagnostic Challenges.Frontiers in cellular neuroscience · 2019Article
- Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2017Article
- Diffusion tensor imaging in patients with obstetric antiphospholipid syndrome without neuropsychiatric symptoms.European radiology · 2016Observational
- Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE.Frontiers in immunology · 2016Review
- Neuroantibody biomarkers: links and challenges in environmental neurodegeneration and autoimmunity.Autoimmune diseases · 2014Review
- Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Increased anti-phospholipid antibodies in autism spectrum disorders.Mediators of inflammation · 2013Article
- Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overview.Yonsei medical journal · 2007Review
- Close association between valvar heart disease and central nervous system manifestations in the antiphospholipid syndrome.Annals of the rheumatic diseases · 2005Article
- Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyclonal anticardiolipin antibodies purified from pooled serum samples of patients with systemic lupus erythematosus were shown to have inhibitory effects on cultured normal rat brain astrocytes (RBA-1 cells). Anticardiolipin antibodies at concentrations from 50 to 200 micrograms/ml inhibited the [3H]thymidine incorporation of RBA-1 cells in a dose dependent manner after three days of culture. A kinetic study showed that anticardiolipin antibodies (100 micrograms/ml) maximally inhibit the proliferation of RBA-1 cells (20.6 (5.1)% of the control value) after incubation for one day. In contrast, human gamma globulin (100 micrograms/ml) had no effect on these cells. In the presence of anticardiolipin antibodies (100 micrograms/ml), the RBA-1 cells attached to the bottom of wells became spherical and the expression of glial fibrillary acidic protein in the cytoplasm was slightly reduced. Using 3,3'-dihexyloxacarbocyanine iodide as an indicator, anticardiolipin antibodies depolarised the membrane potential of RBA-1 cells after one day of culture. In addition, the percentage binding of RBA-1 cells with anticardiolipin antibodies was greater than with gamma globulin as determined by flow cytometric analysis. Immunofluorescence staining of brain tissue from BALB/c mice with anticardiolipin antibodies was noted in the corpus callosum, the cellular zone near the corpus callosum, and cells scattered in brain tissue. These results suggest that anticardiolipin antibodies have an inhibitory effect on brain cells and elicit thrombus formation in brain vessels, which plays a part in neuropsychiatric lupus.
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