ArticleThe EMBO journal2005
The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Frizzled receptors: gatekeepers of Wnt signaling in development and disease.Frontiers in cell and developmental biology · 2025Review
- Frizzled2 receives WntA signaling during butterfly wing pattern formation.Development (Cambridge, England) · 2023Article
- Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments.ACS pharmacology & translational science · 2021Article
- G-Protein Coupled Receptors (GPCRs) in Insects-A Potential Target for New Insecticide Development.Molecules (Basel, Switzerland) · 2021Review
- A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia.BMC medical genetics · 2019Article
- Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.The Journal of biological chemistry · 2018Article
- Review
- Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.British journal of pharmacology · 2017Review
- Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain.Oncotarget · 2017Article
- Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.Genes & development · 2017Article
- A novel bidirectional positive-feedback loop between Wnt-β-catenin and EGFR-ERK plays a role in context-specific modulation of epithelial tissue regeneration.Journal of cell science · 2014Article
- Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.BMC biology · 2014Article
- Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.Cellular signalling · 2014Article
- Wingless/Wnt signaling in Drosophila: the pattern and the pathway.Molecular reproduction and development · 2013Review
- Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.Developmental cell · 2013Article
- Frizzled receptors signal through G proteins.Cellular signalling · 2013Article
- Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Article
- Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing.Fibrogenesis & tissue repair · 2012Article
- Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Frizzled (Fz) receptors contain seven transmembrane helices and an amino-terminal cysteine-rich domain (CRD) that is sufficient and necessary for binding of the ligands, the Wnts. Recent genetic experiments have suggested, however, that the CRD is dispensable for signaling. We engineered fz CRD mutant transgenes and tested them for Wg signaling activity. None of the mutants was functional in cell culture or could fully replace fz in vivo. We also show that replacing the CRD with a structurally distinct Wnt-binding domain, the Wnt inhibitory factor, reconstitutes a functional Wg receptor. We therefore hypothesized that the function of the CRD is to bring Wg in close proximity with the membrane portion of the receptor. We tested this model by substituting Wg itself for the CRD, a manipulation that results in a constitutively active receptor. We propose that Fz activates signaling in two steps: Fz uses its CRD to capture Wg, and once bound Wg interacts with the membrane portion of the receptor to initiate signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.