Trial reportJournal of perinatology : official journal of the California Perinatal Association2005
Surfactant administration by transient intubation in infants 29 to 35 weeks' gestation with respiratory distress syndrome decreases the likelihood of later mechanical ventilation: a randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 9 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Comparative effectiveness of nasal intermittent positive pressure ventilation vs continuous positive airway pressure in preterm infants with RDS: an updated systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2025Pooled it
- Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2024Pooled it
- Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2021Pooled it
- Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.The Cochrane database of systematic reviews · 2012Pooled it
- Nebulised surfactant in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2012Pooled it
- Pharyngeal instillation of surfactant before the first breath for prevention of morbidity and mortality in preterm infants at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Intra-amniotic surfactant for women at risk of preterm birth for preventing respiratory distress in newborns.The Cochrane database of systematic reviews · 2010Pooled it
- Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome.The Cochrane database of systematic reviews · 2007Pooled it
- Continuous positive airway pressure: early, late, or stay with synchronized intermittent mandatory ventilation?Journal of perinatology : official journal of the California Perinatal Association · 2006Pooled it
- Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2019Trial
- The OPTIMIST-A trial: evaluation of minimally-invasive surfactant therapy in preterm infants 25-28 weeks gestation.BMC pediatrics · 2014Trial
- Surfactant administration by transient intubation in infants 29 to 35 weeks' gestation with respiratory distress syndrome decreases the likelihood of later mechanical ventilation: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2005Trial
- Prophylactic surfactant therapy in the era of less invasive surfactant delivery.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Article
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
- Examining Variations in Surfactant Administration (ENVISION): A Neonatology Insights Pilot Project.Children (Basel, Switzerland) · 2021Article
- The Comparison of LISA and INSURE techniques in term of neonatal morbidities and mortality among premature infants.Acta bio-medica : Atenei Parmensis · 2020Article
- A new clinical respiratory distress score for surfactant therapy in preterm infants with respiratory distress.European journal of pediatrics · 2020Observational
- Comparison of NIV-NAVA and NCPAP in facilitating extubation for very preterm infants.BMC pediatrics · 2019Article
- Criteria for Using INSURE in Management of Premature Babies with Respiratory Distress Syndrome.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess, among premature infants with early respiratory distress syndrome (RDS), the effect of one dose of intratracheally administered surfactant followed by extubation to nasal continuous positive airway pressure (NCPAP) on subsequent mechanical ventilation (MV), when compared with NCPAP alone. STUDY
designRandomized, blinded trial in infants 29 to 35 weeks' gestation with mild-to-moderate RDS requiring supplemental oxygen and NCPAP. Infants were randomized to intubation, surfactant treatment, and immediate extubation (surfactant group N=52), or to no intervention (control group N=53). All infants were subsequently managed with NCPAP.
resultsNeed for later MV was 70% in the control group and 50% in the surfactant group. Surfactant group subjects had lower inspired oxygen fraction (FiO(2)) after study intervention and were less likely to require subsequent surfactant. Overall surfactant use, duration of O(2) therapy, length of stay, and bronchopulmonary dysplasia were unaffected.
conclusionAmong premature infants with mild-to-moderate RDS, transient intubation for surfactant administration reduces later MV.
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