Trial reportJournal of perinatology : official journal of the California Perinatal Association2005
Randomized, multicenter trial of conventional ventilation versus high-frequency oscillatory ventilation for the early management of respiratory failure in term or near-term infants in Colombia.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- High-frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term.The Cochrane database of systematic reviews · 2025Pooled it
- Invasive ventilation modes in children: a systematic review and meta-analysis.Critical care (London, England) · 2011Pooled it
- High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term.The Cochrane database of systematic reviews · 2009Pooled it
- Gas transport mechanisms during high-frequency ventilation.Respiratory research · 2024Review
- Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function.Journal of tissue engineering and regenerative medicine · 2017Article
- Comparison of High Frequency Positive Pressure Mechanical Ventilation (HFPPV) With Conventional Method in the Treatment of Neonatal Respiratory Failure.Iranian Red Crescent medical journal · 2013Article
- Neonatal ventilatory techniques - which are best for infants born at term?Archives of medical science : AMS · 2011Article
- Building global health through a center-without-walls: the Vanderbilt Institute for Global Health.Academic medicine : journal of the Association of American Medical Colleges · 2008Article
- International collaborative research: a Colombian model that promotes infant health and research capacity.Journal of perinatology : official journal of the California Perinatal Association · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the efficacy and safety of high-frequency oscillatory ventilation (HFOV) compared to conventional ventilation (CV) for the treatment of respiratory failure in term and near-term infants in Colombia. STUDY
designEligible infants with moderate to severe respiratory failure were randomized to early treatment with CV or HFOV. Ventilator management and general patient care were standardized. The main outcome was neonatal death or pulmonary air leak.
resultsA total of 119 infants were enrolled (55 in the HFOV group; 64 in the CV group) during the study period. Six infants in the HFOV group (11%) and two infants in the CV group (3%) developed the primary outcome (RR: 3.6, 95% CI: 0.8-16.9). Five infants in the HFOV group (9%) and one infant in the CV (2%) died before 28 days of life (RR: 5.9 CI: 0.7-48.2). Secondary outcomes were similar between groups.
conclusionHFOV may not be superior to CV as an early treatment for respiratory failure in this age group. Standardization of ventilator management and general patient care may have a greater impact on the outcome in Colombia than mode of ventilation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.