Evidence map›Paper›PMID 16162953›Full record

ReviewGut2005

Psychological stress in IBD: new insights into pathogenic and therapeutic implications.

J E Mawdsley, D S Rampton

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00553163 (Hypnotherapy for Prevention of Relapse in Ulcerative Colitis), which is not on this map. Cited by 259 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 7 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00553163 naterminatednot on this mapstarted 2007, after this paper: background citation

Hypnotherapy for Prevention of Relapse in Ulcerative Colitis: a Randomised, Single-blind, Controlled Clinical Trial

TypeinterventionalSponsorQueen Mary University of LondonRan2007 to 2010Enrolled26ConditionsUlcerative ColitisArmsGut focussed hypnotherapy, Control educational sessions
3 · Its place in the literature

Who cites it

259 citing papers in PubMed, 7 syntheses or guidelines pooled it, 608 citations in OpenAlex.

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199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J E MawdsleyCentre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.
D S Rampton
Queen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychological stress has long been reported anecdotally to increase disease activity in inflammatory bowel disease (IBD), and recent well designed studies have confirmed that adverse life events, chronic stress, and depression increase the likelihood of relapse in patients with quiescent IBD. This evidence is increasingly supported by studies of experimental stress in animal models of colitis. With the evolving concept of psychoneuroimmunology, the mechanisms by which the nervous system can affect immune function at both systemic and gut mucosal levels are gradually becoming apparent. Recent data suggest that stress induced alterations in gastrointestinal inflammation may be mediated through changes in hypothalamic-pituitary-adrenal (HPA) axis function and alterations in bacterial-mucosal interactions, and via mucosal mast cells and mediators such as corticotrophin releasing factor (CRF). To date, the therapeutic opportunities offered by stress reduction therapy remain largely unexplored, in part because of methodological difficulties of such studies. This paper reviews recent advances in our understanding of the pathogenic role of psychological stress in IBD and emphasises the need for controlled studies of the therapeutic potential of stress reduction.

Indexed as

Acute DiseaseAnimalsChronic DiseaseColitis, UlcerativeCrohn DiseaseDisease Models, AnimalGastrointestinal MotilityGastrointestinal TractHumansHypothalamo-Hypophyseal SystemInflammatory Bowel DiseasesIntestinal MucosaLife Change EventsPituitary-Adrenal SystemStress, Psychological

Identifiers

PMID16162953
PMCPMC1774724
OpenAlexW1974161819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.