ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Genetic enhancement of visual learning by activation of protein kinase C pathways in small groups of rat cortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Rac1 is a downstream effector of PKCα in structural synaptic plasticity.Scientific reports · 2020Article
- Efficient gene transfers into neocortical neurons connected by NMDA NR1-containing synapses.Journal of neuroscience methods · 2019Article
- Separate Gene Transfers into Pre- and Postsynaptic Neocortical Neurons Connected by mGluR5-Containing Synapses.Journal of molecular neuroscience : MN · 2019Article
- TrkB Activation during a Critical Period Mimics the Protective Effects of Early Visual Experience on Perception and the Stability of Receptive Fields in Adult Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Delivery of different genes into pre- and post-synaptic neocortical interneurons connected by GABAergic synapses.PloS one · 2019Article
- Characteristic and intermingled neocortical circuits encode different visual object discriminations.Behavioural brain research · 2017Article
- Neurons can be labeled with unique hues by helper virus-free HSV-1 vectors expressing Brainbow.Journal of neuroscience methods · 2015Article
- Targeted gene transfer of different genes to presynaptic and postsynaptic neocortical neurons connected by a glutamatergic synapse.Brain research · 2012Article
- Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity.Psychopharmacology · 2012Article
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- Reduced activity of protein kinase C in the frontal cortex of subjects with regressive autism: relationship with developmental abnormalities.International journal of biological sciences · 2012Article
- Antibody-mediated targeted gene transfer of helper virus-free HSV-1 vectors to rat neocortical neurons that contain either NMDA receptor 2B or 2A subunits.Brain research · 2011Article
- A 16 bp upstream sequence from the rat tyrosine hydroxylase promoter supports long-term expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system.Brain research · 2011Article
- The vesicular glutamate transporter-1 upstream promoter and first intron each support glutamatergic-specific expression in rat postrhinal cortex.Brain research · 2011Article
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- The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea.Molecular brain · 2010Article
- Identified circuit in rat postrhinal cortex encodes essential information for performing specific visual shape discriminations.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A helper virus-free HSV-1 vector containing the vesicular glutamate transporter-1 promoter supports expression preferentially in VGLUT1-containing glutamatergic neurons.Brain research · 2010Article
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Authors and funding
10 authors.
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Abstract
Although learning and memory theories hypothesize that memories are encoded by specific circuits, it has proven difficult to localize learning within a cortical area. Neural network theories predict that activation of a small fraction of the neurons in a circuit can activate that circuit. Consequently, altering the physiology of a small group of neurons might potentiate a specific circuit and enhance learning, thereby localizing learning to that circuit. In this study, we activated protein kinase C (PKC) pathways in small groups of neurons in rat postrhinal (POR) cortex. We microinjected helper virus-free herpes simplex virus vectors that expressed a constitutively active PKC into POR cortex. This PKC was expressed predominantly in glutamatergic and GABAergic neurons in POR cortex. This intervention increased phosphorylation of five PKC substrates that play critical roles in neurotransmitter release (GAP-43 and dynamin) or glutamatergic neurotransmission (specific subunits of AMPA or NMDA receptors and myristoylated alanine-rich C kinase substrate). Additionally, activation of PKC pathways in cultured cortical neurons supported activation-dependent increases in release of glutamate and GABA. This intervention enhanced the learning rate and accuracy of visual object discriminations. In individual rats, the numbers of transfected neurons positively correlated with this learning. During learning, neuronal activity was increased in neurons proximal to the transfected neurons. These results demonstrate that potentiating small groups of glutamatergic and GABAergic neurons in POR cortex enhances visual object learning. More generally, these results suggest that learning can be mediated by specific cortical circuits.
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