ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 169 citations in OpenAlex.
- BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.Alcohol, clinical & experimental research · 2024Article
- GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses.Frontiers in synaptic neuroscience · 2023Article
- NMDA Receptors Containing GluN2B/2C/2D Subunits Mediate an Increase in Glutamate Release at Hippocampal CA3-CA1 Synapses.Molecular neurobiology · 2019Article
- Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats.Drug design, development and therapy · 2019Article
- Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.ACS chemical neuroscience · 2018Article
- Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability.Cellular and molecular life sciences : CMLS · 2018Review
- Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- A family of photoswitchable NMDA receptors.eLife · 2016Article
- Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.Brain research bulletin · 2015Article
- GluN2A/B ratio elevation induced by cortical spreading depression: electrophysiological and quantitative studies of the hippocampus.The journal of physiological sciences : JPS · 2015Article
- Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.The Journal of pharmacology and experimental therapeutics · 2015Article
- Mechanisms of Neuroplasticity and Ethanol's Effects on Plasticity in the Striatum and Bed Nucleus of the Stria Terminalis.Alcohol research : current reviews · 2015Article
- Dopamine decreases NMDA currents in the oval bed nucleus of the stria terminalis of cocaine self-administering rats.Progress in neuro-psychopharmacology & biological psychiatry · 2014Article
- Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons.Neuropharmacology · 2014Article
- Recent progress in understanding subtype specific regulation of NMDA receptors by G Protein Coupled Receptors (GPCRs).International journal of molecular sciences · 2014Review
- Dopamine-enabled anti-Hebbian timing-dependent plasticity in prefrontal circuitry.Frontiers in neural circuits · 2014Article
- Article
- Characterization of senescence-accelerated mouse prone 6 (SAMP6) as an animal model for brain research.Experimental animals · 2014Review
- GluN2A versus GluN2B: twins, but quite different.Neuroscience bulletin · 2013Review
- Influence of GluN2 subunit identity on NMDA receptor function.Neuropharmacology · 2013Review
29 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Activation of NMDA receptors (NMDARs) within the CNS represents a major signal for persistent alterations in glutamatergic signaling, such as long-term potentiation (LTP) and long-term depression. NMDARs are composed of a combination of NR1 and NR2 subunits, with distinct NR2 subunits imparting distinct characteristics on the receptor. One particular NR2 subunit, NR2A (NRepsilon1), has been proposed to play an integral role in LTP induction in the hippocampus and cortex. Here, we report studies investigating the role of NR2A in LTP induction in the dorsolateral bed nucleus of the stria terminalis (dlBNST). The putative NR2A-specific inhibitor NVP-AAM077 (AAM077) has been used previously to demonstrate the dependence of cortical and hippocampal LTP on NMDARs containing NR2A subunits. We report here the same sensitivity of LTP to pretreatment with AAM077 (0.4 microm) in the dlBNST. However, inconsistent with the conclusion that LTP in the dlBNST is NR2A dependent, we see intact LTP in the dlBNST of NR2A knock-out mice. Because we also see blockade of this dlBNST LTP in NR2A knock-out mice after pretreatment with AAM077, we conclude that the antagonist is targeting non-NR2A subunit-containing receptors. Using a variety of cultured cell types, we find that AAM077 (0.4 microm) can attenuate transmission of NR2B subunit-containing NMDARs when preapplied rather than coapplied with an agonist. Therefore, we conclude that NR2A is not obligatory for the induction of LTP in the dlBNST. Furthermore, our data demonstrate that care must be exercised in the interpretation of data generated with AAM077 when the compound is applied before an agonist.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.