ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Chemosensory coding by neurons in the coeloconic sensilla of the Drosophila antenna.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.
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Who cites it
149 citing papers in PubMed.
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- Morphological Characterization of the Sensilla from the Antennal Flagella, Maxillary Palps, and Aculei, and Electroantennogram Responses of Anastrepha obliqua (Diptera: Tephritidae) to Host Volatiles.Neotropical entomology · 2025Article
- Pheromone-Binding Proteins in Pest Control: From Molecular Insights to Real-World Applications.Journal of agricultural and food chemistry · 2025Review
- Odorant Receptors Mediating Avoidance of Toxic Mustard Oils in Drosophila melanogaster Are Expanded in Herbivorous Relatives.Molecular biology and evolution · 2025Article
- Transcriptome Screening and Identification of Chemosensory Genes in the Goji Berry Psyllid,Biology · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Article
- Olfactory variation among closely related cactophilic Drosophila species.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Ionotropic Receptor Genes in Fig Wasps: Evolutionary Insights from Comparative Studies.Insects · 2025Article
- Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors.Biological research · 2025Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights.International journal of molecular sciences · 2025Article
- Article
- Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster.The European journal of neuroscience · 2025Article
- Functional characterization and evolution of olfactory responses in coeloconic sensilla of the global fruit pest Drosophila suzukii.BMC biology · 2025Article
- An integrated anatomical, functional and evolutionary view of thebioRxiv : the preprint server for biology · 2025Article
- Antennal sensilla diversity in diurnal and nocturnal fireflies (Coleoptera, Lampyridae).PloS one · 2025Article
- IRoning out mosquitoes' attraction to mugginess.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Specialized structure and function of the apical extracellular matrix at sense organs.Cells & development · 2024Review
89 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Odor coding is based on the diverse sensitivities and response properties of olfactory receptor neurons (ORNs). In the Drosophila antenna, ORNs are housed in three major morphological types of sensilla. Although investigation of the Drosophila olfactory system has been expanding rapidly, the ORNs in one of these types, the coeloconic sensilla, have been essentially unexplored. We define four functional types of coeloconic sensilla through extracellular physiological recordings. Each type contains at least two neurons, with a total of at least seven distinct ORN classes that vary remarkably in their breadth of tuning. Analysis of 315 odorant-ORN combinations reveals how these neurons sample odor space via both excitation and inhibition. We identify a class of neurons that is narrowly tuned to small amines, and we find humidity detectors that define a cellular basis for hygroreception in Drosophila. The temporal dynamics of responses vary widely, enhancing the potential for complexity in the odor code. Molecular and genetic analysis shows that a broadly tuned ORN, antennal coeloconic 3B (ac3B), requires the odor receptor gene Or35a for its response in vivo. The activity of ac3B is not required for the response of the other ORN within that sensillum, ac3A. The functional analysis presented here, revealing a combination of highly specialized neurons and a broadly tuned ORN, along with the ancient origin of coeloconic sensilla, suggests that the specificities of these ORNs may reflect basic needs of an ancestral insect.
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