ReviewImmunology2005
Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues.
Review in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- High-Precision Intrinsic Interactome Elucidation of Chimeric Antigen Receptors via Photocatalytic Micromapping (μMap-CAR).Journal of the American Chemical Society · 2026Article
- Epithelial MLCK deficiency alleviates alcohol-associated liver disease via dendritic-Th17 cell axis.JHEP reports : innovation in hepatology · 2026Article
- KIF14 in cancer biology: implications for diagnosis and therapy.Clinical & experimental metastasis · 2026Review
- The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling.Nature communications · 2025Article
- Elucidating immune-related gene transcriptional programs via factorization of large-scale RNA-profiles.iScience · 2024Article
- Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens.Frontiers in immunology · 2024Article
- HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues.Pathogens (Basel, Switzerland) · 2023Review
- Integrin Regulators in Neutrophils.Cells · 2022Review
- Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion.PloS one · 2017Article
- Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- SNX17 affects T cell activation by regulating TCR and integrin recycling.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression.PLoS pathogens · 2013Article
- KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.The Journal of cell biology · 2012Article
- Opposing roles for RhoH GTPase during T-cell migration and activation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation.PloS one · 2012Article
- Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis.PLoS pathogens · 2011Article
- GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice.Nature medicine · 2011Article
- Two-photon microscopy analysis of leukocyte trafficking and motility.Seminars in immunopathology · 2010Review
- Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila.Developmental biology · 2009Article
- EPAC proteins transduce diverse cellular actions of cAMP.British journal of pharmacology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rap1 has emerged as an important regulator of adhesion in multicellular organisms. In the immune system, Rap1 functions as an inside-out signalling molecule for leucocyte integrins following stimulation with chemokines or antigens. Regulator of adhesion and cell polarization enriched in lymphoid tissues (RAPL) is a novel Rap1 effector molecule that mediates Rap1 signalling to integrins. The Rap1-RAPL complex regulates the spatial distribution of the integrin lymphocyte function-associated antigen-1 as well as cell polarization. The linking of inside-out signalling with polarization synergistically promotes highly efficient lymphocyte trafficking. Targeted deletion of RAPL in mice has demonstrated multiple indispensable roles for this protein in lymphocyte and dendritic cell trafficking critical for immunosurveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.