Evidence map›Paper›PMID 16160912›Full record

Trial reportJournal of clinical immunology2005

The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion.

Fiona K Gibbons, Elliot Israel, Aaron Deykin, Bianca Schaub, Hong Z He, David L Perkins, Patricia W Finn

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Journal of clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fiona K GibbonsPulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA. fgibbons@partners.org
Elliot Israel
Aaron Deykin
Bianca Schaub
Hong Z He
David L Perkins
Patricia W Finn
Brigham and Women's Hospital · USHarvard University · USMassachusetts General Hospital · US

Funding

INFORMATIVE STUDIES IN CLINICAL ASTHMAU10HL051831 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT · 1993 to 2002
$2.9M
Modification of Allergic Immunologic Response by LeukotR01HL067684 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FINN, PATRICIA W · 2001 to 2004
$1.5M
NFKB--EPIDEMIOLOGIC &IMMUNOLOGIC ROLE IN EARLY ASTHMAR01AI045007 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FINN, PATRICIA W · 1999 to 2002
$809k
NHLBI NIH HHS 5R01HL067684-02NHLBI NIH HHS 5U10HL051831NIAID NIH HHS 5R01AI045007-04
6 · The paper itself

Abstract

Therapy for asthma often includes the combined use of glucocorticoids and leukotriene receptor antagonists. The short-term, combined effects of these drugs on cytokine secretion and lymphocyte proliferation are ill-defined. The aim of this study was to analyze allergen and mitogen-induced cytokine secretion and lymphocyte proliferation in asthmatics and to determine the effect of combined therapy on these immune responses. Peripheral blood mononuclear cells were isolated from mild, persistent adult asthmatics (n = 28) and analyzed for cat allergen (Fel d 1) and mitogen (phytohemagglutinin) induced IL-13 and IFN-gamma secretion and lymphocyte proliferation. Samples were analyzed before and after 10 days of therapy with oral zafirlukast, prednisone (0.5 mg/kg/day), and inhaled budesonide (1600 mcg/day). Both Fel d 1 and mitogen stimulation resulted in IL-13 and IFN-gamma secretion. Combination drug therapy resulted in a significant decrease in allergen-induced IFN-gamma secretion (p = 0.018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response.

Indexed as

Administration, InhalationAdolescentAdultAgedAsthmaBudesonideDrug Therapy, CombinationFemaleGlucocorticoidsGlycoproteinsHumansIndolesInterferon-gammaInterleukin-13Leukocytes, MononuclearLeukotriene AntagonistsBudesonideFel d 1 protein, Felis domesticusGlucocorticoidsGlycoproteinsIndolesInterferon-gammaInterleukin-13Leukotriene AntagonistsPhenylcarbamatesPhytohemagglutininsPrednisoneSulfonamidesTosyl Compoundszafirlukast

Identifiers

PMID16160912
OpenAlexW1985654647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.