Evidence map›Paper›PMID 16160187›Full record

ArticleJournal of virology2005

Conversion of mouse mammary tumor virus to a lymphomagenic virus.

Sanchita Bhadra, Mary M Lozano, Jaquelin P Dudley

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sanchita BhadraSection of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712-0162, USA.
Mary M Lozano
Jaquelin P Dudley
The University of Texas at Austin · US

Funding

THYMUS INFECTION AND IMMUNITY IN VIRAL LEUKEMOGENESISP01CA077760 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 2000 to 2004
$4.4M
TRANSCRIPTIONAL REGULATION AND TUMORIGENESIS BY MMTVR01CA034780 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI DUDLEY, JAQUELIN PAGE · 1985 to 2002
$821k
NCI NIH HHS P01 CA077760NCI NIH HHS P01 CA77760NCI NIH HHS R01 CA34780
6 · The paper itself

Abstract

Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.

Indexed as

Genes, RegulatorTerminal Repeat SequencesAnimalsCell LineEnhancer Elements, GeneticHumansJurkat CellsLymphoma, T-CellMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMice, Inbred BALB CProvirusesRetroviridae InfectionsT-LymphocytesTranscription, Genetic

Identifiers

PMID16160187
PMCPMC1211542
OpenAlexW2148559871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.