ArticleJournal of bacteriology2005
The pCoo plasmid of enterotoxigenic Escherichia coli is a mosaic cointegrate.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Intracellular competition shapes plasmid population dynamics.Science (New York, N.Y.) · 2025Article
- Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.Nature communications · 2025Article
- Comprehensive genomic analysis of type VI secretion system diversity and associated proteins inMicrobial genomics · 2025Article
- Updates on the Virulence Factors Produced by Multidrug-ResistantMicroorganisms · 2023Review
- A mathematician's guide to plasmids: an introduction to plasmid biology for modellers.Microbiology (Reading, England) · 2023Review
- Non-antibiotic pharmaceuticals promote the transmission of multidrug resistance plasmids through intra- and intergenera conjugation.The ISME journal · 2021Article
- Mechanisms of Theta Plasmid Replication in Enterobacteria and Implications for Adaptation to Its Host.EcoSal Plus · 2020Review
- Article
- Emergence of β-lactamase- and carbapenemase- producing Enterobacteriaceae at integrated fish farms.Antimicrobial resistance and infection control · 2020Article
- Anaerobic Degradation of Syringic Acid by an Adapted Strain of Rhodopseudomonas palustris.Applied and environmental microbiology · 2020Article
- Article
- Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile.PLoS neglected tropical diseases · 2019Article
- Going around in circles: virulence plasmids in enteric pathogens.Nature reviews. Microbiology · 2018Review
- Molecular characterization of Carbapenem resistant Escherichia coli recovered from a tertiary hospital in Lebanon.PloS one · 2018Article
- Molecular and Phenotypic Characterization of DiarrheagenicThe American journal of tropical medicine and hygiene · 2017Article
- Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli.Scientific reports · 2017Article
- Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.ChemMedChem · 2016Article
- Characterization of an Enterobacter cloacae Strain Producing both KPC and NDM Carbapenemases by Whole-Genome Sequencing.Antimicrobial agents and chemotherapy · 2015Article
- Molecular Characterization of Enterotoxin-Producing Escherichia coli Collected in 2011-2012, Russia.PloS one · 2015Article
- Characterization of unstable pEntYN10 from enterotoxigenic Escherichia coli (ETEC) O169:H41.Virulence · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
CS1 is the prototype of a class of pili of enterotoxigenic Escherichia coli (ETEC) associated with diarrheal disease in humans. The genes encoding this pilus are carried on a large plasmid, pCoo. We report the sequence of the complete 98,396-bp plasmid. Like many other virulence plasmids, pCoo is a mosaic consisting of regions derived from multiple sources. Complete and fragmented insertion sequences (IS) make up 24% of the total DNA and are scattered throughout the plasmid. The pCoo DNA between these IS elements has a wide range of G+C content (35 to 57%), suggesting that these regions have different ancestries. We find that the pCoo plasmid is a cointegrate of two functional replicons, related to R64 and R100, which are joined at a 1,953-bp direct repeat of IS100. Recombination between these repeats in the cointegrate generates the two smaller replicons which coexist with the cointegrate in the culture. Both of the smaller replicons have plasmid stability genes as well as genes that may be important in pathogenesis. Examination by PCR of 17 other unrelated CS1 ETEC strains with a variety of serotypes demonstrated that all contained at least parts of both replicons of pCoo and that strains of the O6 genotype appear to contain a cointegrate very similar to pCoo. The results suggest that this family of CS1-encoding plasmids is evolving rapidly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.