ArticleImmunogenetics2005
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- The influence of extrinsic apoptosis gene expression on immunological reconstitution of male ART-treated PLHIV.BMC infectious diseases · 2025Article
- Review
- CD4+ cells recovery in HIV positive patients with severe immunosuppression at HAART initiation at Centre Medico-Social Cor-Unum, Kigali.The Pan African medical journal · 2017Article
- Associations of host genetic variants on CD4⁺ lymphocyte count and plasma HIV-1 RNA in antiretroviral naïve children.The Pediatric infectious disease journal · 2014Article
- Apoptotic mediators in patients with severe and non-severe dengue from Brazil.Journal of medical virology · 2014Article
- Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients.AIDS research and human retroviruses · 2013Article
- FAS and FASL gene polymorphisms are not associated with hepatitis B virus infection based on a case-control study in a Brazilian population.Disease markers · 2013Article
- Poor immune reconstitution in HIV-infected patients associates with high percentage of regulatory CD4+ T cells.PloS one · 2013Article
- Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.Journal of virology · 2012Article
- The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART.Genes and immunity · 2012Article
- Article
- Article
- Immunological failure despite virological suppression in HIV seropositive individuals on antiretroviral therapy.Indian journal of sexually transmitted diseases and AIDS · 2011Article
- Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection: Polymorphisms within Fas gene in occult HBV infection.Hepatitis monthly · 2011Article
- Mortality associated with discordant responses to antiretroviral therapy in resource-constrained settings.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- The FAS -670A>G polymorphism influences susceptibility to systemic sclerosis phenotypes.Arthritis and rheumatism · 2009Article
- Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy.Current HIV/AIDS reports · 2007Review
- Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation. A strong debate exists on the importance of Fas/FasL system during HIV infection, which is characterized by the loss of CD4+ T cells directly, or indirectly, caused by the virus. To investigate whether the genetic background of the host plays a role in the immunoreconstitution, we studied the influence of different Fas and FasL polymorphisms on CD4+ T lymphocyte count and plasma viral load following initiation of highly active antiretroviral therapy (HAART) in drug-naïve HIV+ patients. We studied 131 individuals, who were compared to 136 healthy donors. Statistical analysis was performed by using Chi2 test, Fischer's Exact Test, and analysis for repeated measurements. The group of HIV+ patients had an unexpected lower frequency of FasLnt169 polymorphism (delT allele) than healthy controls (p = 0.039). We then observed no significant differences in the immune reconstitution, in terms of CD4+ T cell increase, when the influence of single alleles of the gene Fas or FasL was considered. However, the combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy.
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