ArticleInternational journal of colorectal disease2006
Segmental heterogeneity of electrogenic secretions in human ascending colon and rectum.
Article in International journal of colorectal disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Regulation of Ion Transport in the Intestine by Free Fatty Acid Receptor 2 and 3: Possible Involvement of the Diffuse Chemosensory System.International journal of molecular sciences · 2018Review
- The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine.Journal of neurogastroenterology and motility · 2017Article
- Involvement of the gut chemosensory system in the regulation of colonic anion secretion.BioMed research international · 2015Review
- Membrane protein profiling of human colon reveals distinct regional differences.Molecular & cellular proteomics : MCP · 2014Article
- The effect of acute hypoxia on short-circuit current and epithelial resistivity in biopsies from human colon.Digestive diseases and sciences · 2013Article
- Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase.Digestive diseases and sciences · 2010Article
- Role of plain abdominal radiographs in predicting type of congenital pouch colon.Pediatric radiology · 2010Article
- Differential protein abundance and function of UT-B urea transporters in human colon.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Colonic epithelial ion transport is not affected in patients with diverticulosis.BMC gastroenterology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe have attempted to ascertain putative segmental differences in the secretory responses of the human ascending colon and rectum.
methodsFrom the mucosal biopsy samples of two segments, the short-circuit current (I(sc)) and tissue resistance (R(te)) were compared under control conditions, as well as after the induction of secretion, using a modified Ussing chamber. We also performed semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to detect and quantify transport proteins.
resultsThe spontaneous I(sc) in the ascending colon was found to be greater than that in the rectum (P<0.01), whereas isobutylmethylxanthine/forskolin and carbachol (CCh) induced a greater rise in I(sc) in the rectum than in the ascending colon (P<0.05). When coupled with indomethacin pretreatment, the increase in Delta I(sc) after the addition of CCh and forskolin was significant as compared to that observed without pretreatment (P<0.05). However, in the rectum, the secretory response to CCh and forskolin was abolished to a significant degree by indomethacin (P<0.05). Moreover, these indomethacin-induced changes were reversed by the addition of PGE2. Upon semiquantitative RT-PCR analysis, the amounts of cystic fibrosis transmembrane regulator, KCNQ1, and CLCA1 mRNAs were not found to be different between the two segments.
conclusionThere was a clear segmental heterogeneity with regard to electrogenic secretion in the human colon, and this difference can be explained by differences in the ascending colon and rectum.
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